Here is the peer reviewed data on the effects of Fluoride and the Pineal
Source
Summation - Fluoride & Pineal Gland: (back to top)
“The single animal study of pineal function indicates that fluoride exposure results in altered melatonin production and altered timing of
sexual maturity. Whether fluoride affects pineal function in humans remains to be demonstrated. The two studies of menarcheal age in humans show the
possibility of earlier menarche in some individuals exposed to fluoride, but no definitive statement can be made. Recent information on the role of
the pineal organ in humans suggests that any agent that affects pineal function could affect human health in a variety of ways, including effects on
sexual maturation, calcium metabolism, parathyroid function, postmenopausal osteoporosis, cancer, and psychiatric disease.”
SOURCE: National Research Council. (2006). Fluoride in Drinking Water: A Scientific Review of EPA's Standards. National Academies Press,
Washington D.C. p221-22.
"In conclusion, the human pineal gland contains the highest concentration of fluoride in the body. Fluoride is associated with depressed pineal
melatonin synthesis by prepubertal gerbils and an accelerated onset of sexual maturation in the female gerbil. The results strengthen the hypothesis
that the pineal has a role in the timing of the onset of puberty. Whether or not fluoride interferes with pineal function in humans requires further
investigation."
SOURCE: Luke J. (1997). The Effect of Fluoride on the Physiology of the Pineal Gland. Ph.D. Thesis. University of Surrey, Guildford. p. 177.
Fluoride & Pineal Gland - Never Studied before 1990s: (back to top)
"It is remarkable that the pineal gland has never been analysed separately for F because it has several features which suggest that it could
accumulate F. It has the highest calcium concentration of any normal soft tissue in the body because it calcifies physiologically in the form of
hydroxyapatite (HA). It has a high metabolic activity coupled with a very profuse blood supply: two factors favouring the deposition of F in
mineralizing tissues. The fact that the pineal is outside the blood-brain barrier suggests that pineal HA could sequester F from the bloodstream if it
has the same strong affinity for F as HA in the other mineralizing tissues. The intensity of the toxic effects of most drugs depends upon their
concentration at the site of action. The mineralizing tissues (bone and teeth) accumulate high concentrations of F and are the first to show toxic
reactions to F. Hence, their reactions to F have been especially well studied. If F accumulates in the pineal gland, then this points to a gap in our
knowledge about whether or not F affects pineal physiology. It was the lack of knowledge in this area that prompted my study."
SOURCE: Luke J. (1997). The Effect of Fluoride on the Physiology of the Pineal Gland. Ph.D. Thesis. University of Surrey, Guildford. p. 1-2.
Fluoride & Pineal Gland - Accumulation of Fluoride in Soft Tissue of Pineal Gland: (back to top)
"After half a century of the prophylactic use of fluorides in dentistry, we now know that fluoride readily accumulates in the human pineal gland.
In fact, the aged pineal contains more fluoride than any other normal soft tissue. The concentration of fluoride in the pineal was significantly
higher (p <0.001) than in corresponding muscle, i.e., 296 ± 257 vs. 0.5± 0.4 mg/kg (wet weight) respectively."
SOURCE: Luke J. (1997). The Effect of Fluoride on the Physiology of the Pineal Gland. Ph.D. Thesis. University of Surrey, Guildford. p. 167.
Fluoride & Pineal Gland - Accumulation of Fluoride in Calcified Tissue of Pineal Gland: (back to top)
"In terms of mineralized tissue, the mean fluoride concentration in the pineal calcification was equivalent to that in severely fluorosed bone
and more than four times higher than in corresponding bone ash, i.e., 8,900 ± 7,700 vs. 2,040 ± 1,100 mg/kg, respectively. The calcification in two
of the 11 pineals analysed in this study contained extremely high levels of fluoride: 21,800 and 20,500 mg/kg."
SOURCE: Luke J. (1997). The Effect of Fluoride on the Physiology of the Pineal Gland. Ph.D. Thesis. University of Surrey, Guildford. p. 167.
Fluoride & Pineal Gland - Analagous to Dental Fluorosis? (back to top)
"Fluoride is now introduced at a much earlier stage of human development than ever before and consequently alters the normal
fluoride-pharmacokinetics in infants. But can one dramatically increase the normal fluoride-intake to infants and get away with it? The safety of the
use of fluorides ultimately rests on the assumption that the developing enamel organ is most sensitive to the toxic effects of fluoride. The results
from this study suggest that the pinealocytes may be as susceptible to fluoride as the developing enamel organ."
SOURCE: Luke J. (1997). The Effect of Fluoride on the Physiology of the Pineal Gland. Ph.D. Thesis. University of Surrey, Guildford. p. 176.
"Alongside the calcification in the developing enamel organ, calcification is also occurring in the child's pineal. It is a normal physiological
process. A complex series of enzymatic reactions within the pinealocytes converts the essential amino acid, tryptophan, to a whole family of indoles.
The main pineal hormone is melatonin (MT)... If F accumulates in the pineal gland during early childhood, it could affect pineal indole metabolism in
much the same way that high local concentrations of F in enamel organ and bone affect the metabolism of ameloblasts and osteoblasts."
SOURCE: Luke J. (1997). The Effect of Fluoride on the Physiology of the Pineal Gland. Ph.D. Thesis. University of Surrey, Guildford. p. 5.
"Any adverse physiological effects of fluoride depend upon the c
[edit on 9-6-2009 by Amenti]