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No changes in methylation were observed after in vitro or adult DES exposure. DES has a dual mechanism of action as an endocrine disruptor; DES functions as a classical estrogen and directly stimulates HOXA10 expression with short-term exposure, however, in utero exposure results in hypermethylation of the HOXA10 gene and long-term altered HOXA10 expression. We identify hypermethylation as a novel mechanism of DES-induced altered developmental programming.
BPA affects HOXA10 expression through the HOXA10 ERE and indirectly through the ARE. BPA initially alters HOXA10 expression through the ERE, however, the response is imprinted and uncoupled from estrogen stimulation in the adult.
Originally posted by OhZone
Elusive one, Neander was not the progenator of modern humans.
And if there are any of the mixed varieties still around would you know them if you saw them?
Some folks think that Neander still exists, and is the creature we call Bigfoot.
And you think Cro-Mag mated with them?
These Ogres were likely rapists.