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McCullers and his colleagues published their findings in the advanced, online issue of the Journal of Infectious Diseases. The researchers based the new treatment on growing evidence that beta-lactams are relatively ineffective against secondary pneumonia because the drugs exacerbate inflammation caused by influenza. “With severe secondary pneumonia, it has seemed that physicians do almost everything they can, and it doesn’t work,” McCullers said. “People still die despite treatment with antibiotics that can kill the bacteria. Our research is showing that the intense inflammatory response that is already there from the virus is amplified by the bacterial infection. Treatment with beta-lactams releases bacterial components into the bloodstream; the immune system recognizes them, triggering an inflammatory burst that can be deadly. “Traditional first-line therapy has been based on the belief that the bacteria are bad, so we have to get rid of them as quickly as possible,” McCullers said. “But what we are finding is that maybe it is the inflammation we need to worry about first, and the bacteria second. Protein synthesis inhibitors shut down the bacterial protein-making factory, and they can avoid the inflammatory burst by killing them over days instead of quickly lysing them.” In their experiments, the St. Jude researchers infected mice with a mild form of influenza that restricted itself to the lungs. After a week, the scientists infected the mice with pneumonia bacteria. This sequence mimics how humans with influenza would contract secondary pneumonia. The researchers treated groups of the doubly infected mice with ampicillin, clindamycin, combined clindamycin and ampicillin, or azithromycin. They found that 56 percent of the mice survived with ampicillin treatment, 82 percent survived with clindamycin, 80 percent with clindamycin and ampicillin, and 92 percent with azithromycin. Significantly, while clindamycin and azithromycin both inhibit protein synthesis, azithromycin also has anti-inflammatory properties. Ampicillin aggravated inflammation compared to clindamycin, the researchers confirmed in test tube studies. The investigators also found evidence of increased inflammation in lung cells of ampicillin-treated animals.
Vitamin C - Boosts the immune system and is an antiviral by blocking the enzyme neuraminadase. Viruses need neuraminadase to reproduce. There are anecdotal stories of people taking large amounts of Vitamin C (children ½) surviving the Spanish Flu. Research shows that it may reduce the production of cytokines TNF-a and IL-6. A study on 470 people involved giving the test group 1000 mg hourly for 6 hours and then 1000 mg 3 times daily after reporting flu symptoms. Symptoms decreased by 85%. (Pubmed PMID 10543583, 634178, 16169205, 12876306)
Originally posted by unityemissions
I personally take 5 or more grams daily. If I feel any sort of cold coming on, I double the dosage.
I've been on this high-dosage for the last eight months and have yet to be sick!
Originally posted by DaRAGE
Well i havn't been eating any vitamin c in pill form, or anything good apart from fish oil, i havn't eaten fruit in a long while, i do get some vegies into me here and there, i smoke, drink lots of energy drinks (far more than the recommended dosage), drink alcohol, and have been getting fatter and fatter for about 8 months now, eating lots of packs of salt and vinegar chips, taking my anti-depressants everyday and also lots of pain-killers as i have a really bad neck and back, and this is probably the first time in about 8 months that i've gotten sick and no i havn't been to mexico ;-P
Originally posted by KOGDOG
I eat frozen Orange Juice Concentrate straight from the can with a fork! I love the stuff. If there were a container of my favorite ice cream sitting next to the OJ... I would always choose the OJ.
Summary Lathyrism is characterized by defective collagen synthesis due to inhibition of lysyl oxidase, an enzyme essential for interfibrillar cross-linking. The lathyritic agent bgr-aminoproprionitrile (bgr-APN) is considered an appropriate agent for studying connective tissue metabolism. We investigated the effects of ascorbic acid on collagen structure and serum cytokine levels in experimentally induced lathyrism. Forty Wistar rats weighing 200–300 g were used in the study: three test groups of 10 rats each (groups 2, 3 and 4) and 10 rats used as a control group (group 1). Experimental lathyrism was induced with daily subcutaneous injections of bgr-APN in the test groups for 40 days. On the 40th day, skin biopsies were taken from the control group (group 1) and group 2, to evaluate the effect of bgr-APN on dermal collagen. After the 40th day, 10 rats received ascorbic acid 100 mg/kg intraperitoneally daily for 15 days (group 3) and 10 rats (group 4) received no medication and served as a control for group 3. On the 55th day, skin biopsies were taken from groups 3 and 4. Serum concentrations of interleukin-6 and tumour necrosis factor-agr were assessed in each group by enzyme-linked immunosorbent assay. Ultrastructural examination of the skin biopsies in group 1 revealed normal-appearing epidermal and dermal structures. Group 2 showed disorganization of the epidermis and collagen structure, and vacuolization of the endoplasmic reticulum in fibroblasts. In group 3, ultrastructural examination revealed significant improvement in the structure of dermal collagen after administration of ascorbic acid, whereas the changes in group 4 were unremarkable. Ascorbic acid administration significantly decreased the concentrations of serum cytokines in group 3 compared with group 2 (P < 0.001). Ascorbic acid administration significantly improved dermal collagen structure and serum cytokine levels in experimental lathyrism.
If you are not sick, you should not be taking any. Let your body function normally as is. Let your immune system build a natural strength. It makes no sense to saturate your body with ascorbate if you are well and healthy.
Vitamin-C cures Avian Flu, Polio, etc.?
Klenner successfully treated severe cases of influenza with doses as large as 24 g every 12 hours (Klenner, 1949, 1971). It was also reported that using a few grams per day in treating influenza produced significant results (Albanese, 1947 & Magne, 1963). Moreover, smaller doses such as 300 mg were found to be effective in reducing the duration of the illness by 25 percent (Kimbarowksi and Mokrow, 1967). Investigators have also reported that vitamin C had been used in treating bacterial infections. A study in 1937 showed that an ascorbate concentration of 1 mg per deciliter inhibits the growth of tuberculosis bacterium (Boissevin, Spillane 1937). Likewise, ascorbate has been effective in treating other bacteria and their toxins. The bacteria that cause typhoid fever include diphtheria, tetanus and staphylococcus infections, and their toxins include diphtheria, tetanus, staphylococcus and dysentery and (references are given by Stone, 1972). Bacteria may be inactivated in the same manner ascorbate facilitates inactivation in the virus; free radicals are created by an interaction between ascorbate and oxygen, which is catalyzed by copper ions, and as a result the free radicals attack the bacteria (Pauling, 1976).