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Disodium 5'-ribonucleotides, E number E635, are flavor enhancers which are synergistic with glutamates in creating the taste of umami. It is a mixture of disodium inosinate (IMP) and disodium guanylate (GMP) and is often used where a food already contains natural glutamates (as in meat extract) or added monosodium glutamate.
It is well known that childrens behaviour is directly affected by artificial colourings, sweetners and flavourings. Fizzy drinks, sweets and crisps are the main culprits and there are now organic and chemical free alternatives in supermarkets and health food shops. Here are the main additives to avoid:
Flavour Enhancers: Monosodium glutomate (E621); disodium 5-ribonucleotide (E635); Artificial Sweetners: Sodium benzoate (E211); Sulphur dioxide (E220); aspartame; acesulfame K. Colourings: Yellow (E104), Brilliant blue (E113), sunset yellow (E110), carmoisine (E122), ponceau 4R (E124), allura red AC (E129) and indigo(!) carmine (E132).
Responses to Di-Sodium Guanosine 5'-Monophosphate and Monosodium L-Glutamate in Taste Receptor Cells of Rat Fungiform Papillae. J. Neurophysiol. 89: 1434-1439, 2003. The 5'-ribonucleotide guanosine 5'-monophosphate (GMP) is used widely as an umami taste stimulus and a potent flavor enhancer as it synergistically increases the umami taste elicited by monosodium glutamate. Transduction mechanisms for GMP and its synergy with glutamate are largely unknown. Using whole-cell patch-clamp and Ca2+ imaging, we examined responses to GMP, glutamate, and a mixture of GMP and glutamate in taste-receptor cells of rat fungiform papillae.
As it is a fairly expensive additive, it usually is not used independently of glutamic acid; if disodium inosinate is present in a list of ingredients but MSG does not appear to be, it is possible that glutamic acid is provided as part of another ingredient or is naturally occurring in another ingredient like tomatoes, Parmesan cheese or yeast extract. It is often added to foods in conjunction with disodium guanylate; the combination is known as disodium 5'-ribonucleotides.