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He claimed that his "Protein Metabolism Evaluation Index" could diagnose cancer before it was clinically apparent and that his "Kelley Malignancy Index could detect "the presence or absence of cancer, the growth rate of the tumor, the location of the tumor mass, prognosis of the treatment, age of the tumor and the regulation of medication for treatment."
In 1970, Kelley was convicted of practicing medicine without a license after witnesses testified that he had diagnosed lung cancer on the basis of blood from a patient's finger and prescribed dietary supplements, enzymes, and a diet as treatment. In 1976, following court appeals, his dental license was suspended for five years . However, he continued to promote his methods until the mid-1980s through his Dallas-based International Health Institute. Under the institute's umbrella, licensed professionals and "certified metabolic technicians" throughout the United States would administer a 3,200-item questionnaire and send the answers to Dallas. The resultant computer printout provided a lengthy report on "metabolic status" plus detailed instructions covering foods, supplements (typically 100 to 200 pills per day), "detoxification" techniques, and lifestyle changes.
Treatment said to be similar is still provided today by Nicholas Gonzalez, M.D., of New York City, who claims to have analyzed Kelley's records and drafted a book about his findings. The manuscript was never published, but experts who evaluated its chapter on 50 cases found no evidence of benefit. Gonzalez says that he offers "10 basic diets with 90 variations" and typically prescribes coffee enemas and "up to 150 pills a day in 10 to 12 divided doses."
Originally posted by Phage
reply to post by broli
(...)I am not wealthy. It is the quacks selling snake oil to very, very frightened and confused people who are wealthy. It is they who are providing the "disinfo". But I prefer the term "lies".
Characterization of mitochondrial function in human cancer stem
Peter Dromparis, Gopinath Sutendra, Ken Petruk, Sebastien Bonnet and
INTRODUCTION: In mitochondria-dependent apoptosis, pro-apoptotic
mediators are released upon mitochondrial depolarization. Most cancers have
hyperpolarized mitochondria, an index of apoptosis resistance. The
mitochondrial hyperpolarization also explains the unique metabolism of cancer
cells, i.e. enhanced glycolysis (in the cytoplasm) and suppressed glucose
oxidation (GO, in the mitochondria). The metabolic modulator dichloroacetate
(DCA) increases GO, depolarizes mitochondria, inducing apoptosis and
reversing cancer growth. Cancer stem cells (CSCs) are necessary and sufficient
in the development, progression and recurrence of cancer. CSC mitochondria
have not been studied yet. We hypothesized that CSCs have more
hyperpolarized mitochondria than cancer cells and that DCA depolarizes their
mitochondria, inhibiting CSC survival and differentiation.
METHODS and RESULTS: We developed cancer cell lines from freshly excised
glioblastoma tissues. CSCs were isolated by magnetic bead separation and
expanded in serum-free media supplemented with standard growth factors.
CSCs were characterized by immunocytochemistry criteria and were
differentiated into cancer cells in serum media. Mitochondria membrane
potential was measured with TMRM and confocal microscopy. CSCs formed
non-adhering clusters and stained positive for CD133 and nestin but negative
for GFAP, β-III-tubulin and myelin oligodendrocyte. Differentiated cells attached
on the plate, lost the CSC markers CD133 and nestin and expressed GFAP,
confirming their identity as glioma cells. CSCs had more hyperpolarized
mitochondria compared to both freshly isolated cancer cells and differentiated (...)
Dr. Evangelos Michelakis phoned the pharmacy to say DCA, which shrank tumours in rats but hasn't been tested in humans, could be lethal or cause horrible side-effects.
Originally posted by Phage
reply to post by Rigel
Please provide the name of the clinic and their published results.
[edit on 3/10/2009 by Phage]
While we cannot comment on the cancer- specific response rates with confidence due to the relatively low numbers, our overall positive response rate continues to be between 60 – 70%. A positive response can be in the form of tumour shrinkage, cancer marker reduction, blood test improvement, symptomatic improvement, disease stabilization or a combination of any of these. In 30 - 40% of our patients we have not seen a response to treatment which is similar to our previous experience.
Originally posted by Phage
reply to post by Rigel
You did not mention Dr. Gernez in your original post. Does he claim that cancer has a single cause or a single cure? Unfortunately I do not read French and most everything about him on the internet seems to be in that language.
[edit on 3/10/2009 by Phage]
De 1950 à 1963, le docteur André Gernez établit son cabinet de radiologie à Roubaix. En 1963, il analyse l'autoradiographie par fixation de tritium sur l'ADN cellulaire. L'observation confirme qu'en processus normal, une cellule-mère se divise en deux cellules-filles dont une seule peut se diviser par la suite. Il propose un nouveau postulat sous la forme d'un synoptique sur la cinétique cellulaire et la cancerogénèse.
De 1967 à 1969, les docteurs Gernez et Delahousse soumettent à l'Académie des sciences quatre mémoires intitulés Néo-Postulats Biologiques et Pathogéniques, La Carcinogénèse - Mécanisme et Prévention, Le Cancer - Dynamique et éradication et Loi et Règles de la cancérisation.
Dès 1970, les docteurs Gernez, Delahousse, Lacaze, Dumont (thèse à Lille) et Deston révisent le dogme scientifique de la « neurogénèse » (à savoir le double cycle cellulaire et de la fixité neuronale). En effet, Ramon Cajal avait postulé la fausse affirmation, à savoir que les structures nerveuses étaient fixées et immuables à la naissance. À cette occasion, il constitue l'Union Biologique Internationale avec ses collaborateurs les professeurs Gellé et Nihous, les docteurs Delahousse, Lacaze, Dumont, Deston et Jean-Pierre Willem. Selon les propos du Dr Lacaze, « André Gernez a réalisé un énorme travail de lectures pour synthétiser des évidences »
Le docteur Gernez approfondit ensuite ses travaux sur le cancer, la schizophrénie, la myopathie, le Parkinson, l'alzheimer, le psoriasis, l'asthme, l'allergie et la sclérose en plaques .
Ernst T. Krebs, Jr.—Laetrile's "father"—has often been referred to as "Dr. Krebs" although he has no accredited doctoral degree. He attended Hahnemann Medical College in Philadelphia from 1938 to 1941, but was expelled after repeating his freshman year and failing his sophomore year . After taking courses in five different colleges and achieving low or failing grades in his science courses, he finally received a bachelor of arts degree from the University of Illinois in 1942 . In 1973, after giving a 1-hour lecture on Laetrile, he obtained a "Doctor of Science" degree from American Christian College, a small, now-defunct Bible college in Tulsa, Oklahoma. The school, founded by evangelist Billy James Hargis, had no science department and lacked authority from Oklahoma to grant any doctoral degrees.
In general, prospective studies in which the lowest intake group consumed more than 86 mg of vitamin C daily have not found differences in cancer risk, while studies finding significant cancer risk reductions found them in people consuming at least 80 to 110 mg of vitamin C daily (1).
Studies in the 1970's and 1980's conducted by Linus Pauling and colleagues suggested that very large doses of vitamin C (10 grams/day intravenously for 10 days followed by at least 10 grams/day orally indefinitely) were helpful in increasing the survival time and improving the quality of life of terminal cancer patients (31). However, two randomized placebo-controlled studies conducted at the Mayo clinic found no differences in outcome between terminal cancer patients receiving 10 grams of vitamin C/day orally or placebo (32, 33)
Currently, there are no results from controlled clinical trials indicating that vitamin C would adversely affect the survival of cancer patients. However, vitamin C should not be used in place of therapy that has been demonstrated effective in the treatment of a particular type of cancer, for example, chemotherapy or radiation therapy.
Rath claims to have discovered that high-dose nutritional supplements can block the spread of cancer cells in laboratory conditions (called metastasis when it occurs in the body). He argues that the growth and metastasis of cancer are facilitated when the balance between mechanisms breaking down and building the connective tissue shifts towards breakdown. He points out that the body makes widespread use of these mechanisms during normal (physiological) conditions, e.g. a) during ovulation, when egg cells migrate from the ovary to the fallopian tube; b) during the restructuring of the uterus and the breast in pregnancy and lactation, when huge amounts of tissue have to be remodelled; c) during infections when white blood cells (leucocytes) migrate through the tissue to the site of infection. He argues that in case of cancer, normal control of these mechanisms fails and the tissue degradation continues uncontrolled.
Rath claims that the uncontrolled release of degrading enzymes in cancer can be blocked by the natural amino acid lysine. He says that a high daily intake of lysine – in particular in combination with vitamin C – can block cancer cells from spreading.
Rath has published a series of articles claiming in vitro evidence that supplements can slow the spread of more than 30 cultured, immortalized cell lines derived from human cancers. These studies, Rath claims, have also identified in vitro synergism between lysine, polyphenols and other micronutrients. Organized in vivo clinical studies using this new approach to cancer have not been published. An independent review of Rath's claims by the Swiss Study Group for Complementary and Alternative Methods in Cancer (SKAK) in 2004 found "no proof that the vitamin preparations of Dr. Matthias Rath have any effect on human cancer" and advised against their use.
 Immune deficiencies
Rath and his research team advocate the use of micronutrients to improve the immune response against infections and help fight immune deficiencies. Rath and his colleagues report that chicks infected with avian flu and given a mixture of micronutrients develop audible pulmonary symptoms later than control animals.
In a special feature article published in the 2007 Commonwealth Health Ministers Book, Rath and colleagues claim that "studies conducted with both single and multiple nutritional supplements have shown that micronutrients act to control HIV infection and AIDS in three specific ways, which include: (i) suppression of virus multiplication and spread; (ii) restoration of cell-mediated immune responses and (iii) slowing the rate of AIDS progression and reducing the severity of AIDS-defining and disease-related symptoms."
 International politics
According to Rath, events of the last century in the international arena have been driven by pharmaceutical and oil companies. Rath claims that World War II was started and exploited by these interests. In court filings, Rath and his lawyers write that the pharmaceutical industry then started apartheid in South Africa as part of a global conspiracy to "conquer and control the entire African continent." Former Nazi officials and the German chemical company IG Farben are specifically mentioned as playing a central role in the alleged conspiracy. In these documents, Rath also compares his adversaries in court to Hitler's storm troopers.
Rath suggests that the pharmaceutical industry continues to control international politics today, allowing 9/11 to occur and starting the Iraq War to divert attention from what Rath considers the failures of drug companies. On his website, Rath states that United States President George W. Bush and Vice President Dick Cheney, at the behest of what Rath calls the "pharmaceutical cartel", are planning a nuclear war in advance of the 4 November, 2008 elections in the United States. Similar claims are made by Rath in the New York Times and other major newspapers around the world in the form of large advertisements reportedly designed to resemble newspaper editorials.