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Alzheimer's Prevented And Reversed With Natural Protein In Animal Models

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posted on Feb, 9 2009 @ 10:21 AM
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Alzheimer's Prevented And Reversed With Natural Protein In Animal Models


www.sciencedaily.com

ScienceDaily (Feb. 9, 2009) — Memory loss, cognitive impairment, brain cell degeneration and cell death were prevented or reversed in several animal models after treatment with a naturally occurring protein called brain-derived neurotrophic factor (BDNF). The study by a University of California, San Diego-led team – published in the February 8, 2009 issue of Nature Medicine – shows that BDNF treatment can potentially provide long-lasting protection by slowing, or even stopping the progression of Alzheimer's disease in animal models.

"The effects of BDNF were potent," said Mark Tuszynski, MD, PhD, professor of neurosciences at the UC San Diego School of Medicine and neurologist at the Veterans Affairs San Diego Health System. "When we administered BDNF to memory circuits in the brain, we directly stimulated their activity and prevented cell death from the underlying disease."

BDNF is normally produced throughout life in the entorhinal cortex, a portion of the brain that supports memory. Its production decreases in the presence of Alzheimer's disease. For these experiments, the researchers injected the BDNF gene or protein in a series of cell culture and animal models, including transgenic mouse models of Alzheimer's disease; aged rats; rats with induced damage to the entorhinal cortex; aged rhesus monkeys, and monkeys with entorhinal cortex damage.

In each case, when compared with control groups not treated with BDNF, the treated animals demonstrated significant improvement in the performance of a variety of learning and memory tests. Notably, the brains of the treated animals also exhibited restored BDNF gene expression, enhanced cell size, improved cell signaling, and activation of function in neurons that would otherwise have degenerated, compared to untreated animals. These benefits extended to the degenerating hippocampus where short-term memory is processed, one of the first regions of the brain to suffer damage in Alzheimer's disease.
(visit the link for the full news article)




posted on Feb, 9 2009 @ 10:21 AM
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This is truly fascinating and if the model holds in further trials and especially ones in humans this would be a great breakthrough.

Fortunately neither of my parents have (or had) Alzheimer's but I have known a few people who have and it is heartbreaking to watch a person go that way sinking ever deeper into a dark and clouded mind.

Of course no one will see the benefits of this until the drug pushers figure out a way to make a killing on it.

www.sciencedaily.com
(visit the link for the full news article)



posted on Feb, 9 2009 @ 10:36 AM
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AWESOME! Alzheimer's is a terrible disease that no person, or their loved ones, should have to go through. It is a long-lasting, degenerative disease, that nobody should have to face.

I am most certainly excited to see where this research leads, as Alzheimer's, as far as I know, doesn't have too much in the way of treatment, which for conspiracy minded individual like myself, means that there isn't much profit currently being made off Alzheimer's.

The common cold makes billions upon treating the symptoms of colds, rather than the cold itself, that is why I believe you will never see a cure. AIDS has many medicines to combat it, which generate a life long fund of money. As far as I know, Alzheimer's has no such profitable treatment.

Hopeful news in a dooms day world.



posted on Feb, 9 2009 @ 10:53 AM
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Wow! Wouldn't it be just fantastic if the Pharmaceutical industry and the FDA didn't entangle this potential treatment in their endless commercialization and profit-making efforts?

Imagine the benefits to the millions suffering from various stages of cognitive dysfunction!

Nice find!



posted on Feb, 9 2009 @ 10:55 AM
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There has been quite a lot of positive developments in the AIDS war as well as Alzheimer's and other diseases including diabetes what bites my oh so ample butt though is not that the companies working on these things want to make a profit but rather that they want to make obscene profits from others pain and suffering.

Remember their big stink about ordering prescription drugs from Canada and how foreign made drugs could be unsafe... we most of our drugs are made overseas anyway so their argument was a strawdawg all along that they charge top dollar for.

God forbid that anyone should get their product for anything less than an arm and a leg.



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