reply to post by RedGolem
Well, in doses recommended by manufacturers, under normal (no drug interactions, no certain illnesses) conditions those drugs should not kill
99.9999999... (warning - uneducated guess) of patients. But once you increase number of people who will use it - fatalities can happen. We are all
different inside. Some might be much more prone to side effects. And there are people who do take several drugs - so here adds interactions thingy.
And there are people who have specific problems that will make individual in higher risk groups.
So once drug is taken by larger group of people (not to mention OTC suggestion - why not GSL then???) there is higher chance of someone dieing of it.
In researches by drug companies - even in phase 4 - amount of data is significantly lower then if it is going to be prescribed to increase
concentration to general population.
For example - in methylphenidate - drug went through all the tests, and after decade of usage FDA voted to add black box warning - that it might cause
sudden death/heart stroke and other nice things (oops, black box suggestion was rejected month later). By the way -Adderall also has similar blck box
as i found out.
It does not mean that it will happen often, but it does mean that there is a small chance that it might. Small chance multiplied by larger group of
users - number of people who suffered from it higher.
Plus - there is a tiny chance of depression. Pretty severe depression though. So here added drugs for depression that also have their side effects and
the chances of unwanted outcome rise.
If i would guess - reason for black box arguement was because there were 25 deaths between 1999 and 2003 for unknown reason with people (kids and
adults) that used methylphenidate. From 3 million users.So increase number of users by 10 and number of victims has a chance to rise similarly if it
is correct corelation.
[edit on 13-12-2008 by ZeroKnowledge]