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Antibiotic use has been hypothesized to be associated with the risk of cancer but the evidence is sparse and inconsistent [...] During the period 1998-2004, 134,070 cancer cases were ascertained from the Finnish Cancer Registry. Cox proportional hazards regression was used to estimate the relative risks (RRs) with 95% confidence intervals (95% CIs). Antibiotic use was associated with an increased risk of cancer.