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If you were to make the stretch of Nephilim as crossbread Cromagnon-Neanderthal, I would say such an offspring would, by necessity, be steril. Good workers, perhaps, but not in great enough numbers nor traditional organization (based on bloodlines/lineage) to actually rule. They'd be the lifters, the builders, but not the designers or thinkers.
Originally posted by applebiter
The Nephilim were, in fact, giants. They were larger than either Neanderthal or Cromagnon for the same reason that "ligers" are larger than either lions or tigers. Cromagnon-Neanderthal hybrids carried the best of the cognitive faculties of both species, resulting in a pairing that produced more cognitive horsepower than either of the parent species. Pyramid builders in Egypt are depicted as having coned heads, just as the "white, bearded" gods who brought pyramids and technology to South and Central America.