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Originally posted by pai mei
The "civilized" world ain't so civilized, is it ? Poisoning your own water is not what an advanced civilization does.
Originally posted by qxlb52
But I'd like to see them distinguish between OTC, Prescription, and Narcotic drugs in the water system before I label whole cities as full of drug fiends. Could anyone advise us on the levels of street meth, coke, heroin, and marijuana found?
Originally posted by jkrog08
I also have to mention that Meprobamate is not used much anymore due to the newer Benzodiazipines(Xanax,Valium,Klonopin,Halcion)So I would figure that that drug prolly comes from the metabolization of Soma(Carisoprodol)Which quickly transforms into Mepbrobamate after ingestion.
***Soma is a widely used unschedualed(except for a few states) CNS acting muscle relaxant.It is widely use in combonation with Vicodin(IE:Lortab,Lorcet(Hydrocodone Bitartrate)for its synergizing(intensifying)effects.
The elimination of the muscle relaxant drug, carisoprodol, was examined in 10 healthy volunteers after an oral dose of 700 mg. In nine subjects, carisoprodol was rapidly eliminated, with a mean half-life of 99 +/- 46 min, and extensively converted to meprobamate. Within 2.5 h after carisoprodol intake, meprobamate serum concentrations exceeded those of carisoprodol. Serum levels of meprobamate recorded (15-25 mumol/L) indicate that meprobamate might contribute to the effect(s) of carisoprodol. One subject eliminated carisoprodol with an overall half-life of 376 min, and only small amounts of meprobamate were recorded. This subject was found to be a poor metabolizer of mephenytoin. In spiked human sera, protein binding of carisoprodol was in the range of 41-67%, whereas meprobamate was bound to a lesser extent, 14-24%.
Carisoprodol is a noncontrolled skeletal muscle relaxant whose active metabolite is meprobamate, a Schedule IV controlled substance. Although several case reports have shown that carisoprodol has abuse potential, it continues to be widely prescribed. The usage patterns of 40 patients who had taken carisoprodol for three or more months (20 of whom had no history of substance abuse and 20 of whom carried a diagnosis of substance abuse or dependence) were reviewed and compared and a survey was conducted to assess physician awareness of the abuse potential of the drug. Findings showed that some patients using carisoprodol for over three months may abuse the medication, especially those individuals with a history of substance abuse. A significant percentage of the physician population is unaware of the potential of carisoprodol for abuse and of its metabolism to meprobamate, a controlled substance. Physicians should exercise caution when prescribing carisoprodol, especially if the patient has a history of substance abuse.
Do you know about the generics use of this compound, I'd be interested in your take on this.