Originally posted by Heronumber0
I take your assertion and agree with it to a point. However, the paper you cited is about the rate of mutation in pseudogenes and I would criticise
that study because much of the change in pseudogene sequences may be neutral anyway.
I think this is just a method of assessing mutation rate. These areas are unconstrained, so are the best method of giving an estimate of the true rate
of mutation in the genome. The 3 deleterious mutations is actually a bit higher than previous estimations.
In fact one of the diseases - beta thalassaemia, is caused by a single base pair substitution:
Aye, and being a mere carrier of these genes may actually be beneficial in particular environments. I don't doubt that people suffer from negative
mutations, I actually stated this earlier. But the chances are very high that we all have numerous mutations in our genome, most being pretty
innocuous - well I hope mine are...
1. Is there an obvious link between cholesterol levels and heart disease. Some investigators disagree with this simple association, certainly
in middle-aged men in London, if not elewhere:
OK, I know some people question this, but are you saying that clogged arteries are nothing to worry about, and that protection against this is not
beneficial? This is what this mutation appears to be protecting against. Moroever, I pointed out more than one mutation earlier, so I don't see what
the point of this is, unless it's an obscuration. One study using an APO-milano derived therapy appeared to have positive effects.
The requirement was to point out beneficial mutations, I did so. even if you want to doubt the protection provided by APO-milano, others are still
outstanding. Moreover, I can find more if need be.
2. To successfully spread this gene, the carriers of Apo AI Milano would have to be sexually active up to middle age and have a significant
number of progeny. Europeans do not seem to fall into this categorisation.
Also, I think, from the paper, that this is a rare variant found in one family, so it is not widespread at the moment anyway.
Heh, if we have more males producing babies at age 40-60 (which they can) in one group of people, then over time, this would have an effect. And there
are many men producing babies at this age, indeed, many people are holding off having sprogs until later in their lives (given mostly educated
middle-class - you'd have to watch the film 'Idiocracy' to see how these genes may help - j/k). Moroever, the point earlier was to show a
beneficial mutation, and this is generally accepted as being one, despite possible obscuration.
I had to be exposed to the TV Hogmanay celebrations with kilted men full of whiskey throwing themselves around a room shouting Wheeuch! and Och
Aye! at each other to the accompaniment of the bagpipes - still, we can't all have everything can we?

Heh, sounds painful. If I'm at home, I tend to watch Jools Holland new year, but a nice surprise from RH this year.
[edit on 1-1-2008 by melatonin]