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The ultimate way of preventing the use of HIV as a weapon would be the development of a cure or a vaccine for HIV. Barring a the discovery of a cure for HIV, the best way to prevent the use of weaponized HIV would be through the careful monitoring of infection patterns of HIV as well as through traditional intelligence gathering means to discover such a plot before it can be fully implemented.
Okay lets do some research into depopulation then. Here is an excellent start :