Diabetes breakthrough/Toronto scientists cure disease in mice

The primary point of interest here is that the disease is due to a neurological cause and not autoimmune as originally believed

Lets hope this leads to some major changes in thought and treatment of diabetes

Diabetes breakthrough
Toronto scientists cure disease in mice
Tom Blackwell, National Post
Published: Friday, December 15, 2006

In a discovery that has stunned even those behind it, scientists at a Toronto hospital say they have proof the body's nervous system helps trigger diabetes, opening the door to a potential near-cure of the disease that affects millions of Canadians.

Diabetic mice became healthy virtually overnight after researchers injected a substance to counteract the effect of malfunctioning pain neurons in the pancreas. "I couldn't believe it," said Dr. Michael Salter, a pain expert at the Hospital for Sick Children and one of the scientists. "Mice with diabetes suddenly didn't have diabetes any more."

The researchers caution they have yet to confirm their findings in people, but say they expect results from human studies within a year or so. Any treatment that may emerge to help at least some patients would likely be years away from hitting the market. But the excitement of the team from Sick Kids, whose work is being published today in the journal Cell, is almost palpable.

"I've never seen anything like it," said Dr. Hans Michael Dosch, an immunologist at the hospital and a leader of the studies. "In my career, this is unique." Their conclusions upset conventional wisdom that Type 1 diabetes, the most serious form of the illness that typically first appears in childhood, was solely caused by auto-immune responses -- the body's immune system turning on itself. They also conclude that there are far more similarities than previously thought between Type 1 and Type 2 diabetes, and that nerves likely play a role in other chronic inflammatory conditions, such as asthma and Crohn's disease.

www.canada.com...



[edit on 16-6-2007 by junglelord]

Awesome find as usual, kudos

those are very kind words, thanks


I hope and pray this turns into a comparable results trial with humans.
I will see what more I can find, but I feel this will be pivitol in the search for a cure as we have more then likely looking in the wrong direction


Its important to realize that the capsaicin in chili peppers seems to cause the pancreas to be stimulated.

I wonder if that would translate into dietary intake?

injecting capsaicin, the active ingredient in hot chili peppers, to kill the pancreatic sensory nerves in mice that had an equivalent of Type 1 diabetes. "Then we had the biggest shock of our lives," Dr. Dosch said. Almost immediately, the islets began producing insulin normally "It was a shock ? really out of left field, because nothing in the literature was saying anything about this."

It turns out the nerves secrete neuropeptides that are instrumental in the proper functioning of the islets. Further study by the team, which also involved the University of Calgary and the Jackson Laboratory in Maine, found that the nerves in diabetic mice were releasing too little of the neuropeptides, resulting in a "vicious cycle" of stress on the islets.

So next they injected the neuropeptide "substance P" in the pancreases of diabetic mice, a demanding task given the tiny size of the rodent organs. The results were dramatic. The islet inflammation cleared up and the diabetes was gone. Some have remained in that state for as long as four months, with just one injection.

They also discovered that their treatments curbed the insulin resistance that is the hallmark of Type 2 diabetes, and that insulin resistance is a major factor in Type 1 diabetes, suggesting the two illnesses are quite similar.

[edit on 16-6-2007 by junglelord]

it blows my mind what stays in medical in ATS, and the threads of mine they bounce here

like this
www.abovetopsecret.com...

mods have poor decision processes concering my threads and bouncing.

the forum overviews do not have a link
its like pissing in the wind

I don't make fluffy threads
I give substance and they would rather take something important and bury it and let the dribble slide



[edit on 16-6-2007 by junglelord]

Mod Note: Complaints and How to Contact ATS Staff.

[edit on 16/6/2007 by Umbrax]

Originally posted by junglelord

it blows my mind what stays in medical in ATS

First of all, we don't discuss thread moves in threads. Threads are for topics. Such a discussion is off-topic. You seem to misunderstand something here. ATS is not "the professional" and "important" place while bts is "amateur stuff". You see, ATS is for conspiracies! BTS is for everything else, unless it's political. Political stuff gets moved to abovePolitics. BTS is not bad. BTS is good. Now write this 100 times: " ATS is for conspiracies!" ATS is for conspiracies! ATS is for conspiracies! etc.

Now discuss the topic, please.

you cannot even begin to justify that statement
take a look at the medical catagory
you trying to tell me thats all conspiracy?
thats why the post was thread related..
the fact you moved it is important
the better I understand the proper placement of things the less you will have to do
but to claim ATS is all conspiracy is a load.
even the science section and the space section is up to date information.
its not all about conspiracy
give me abreak
I am looking for the rhyme and the reason
all you gave me is the rhyme with no reason


I think I am done posting valuable information that gets tossed around like a bouncing ball

I wish you well with your site and your decision making process.



my time is too valuable to waste.


[edit on 16-6-2007 by junglelord]

Originally posted by junglelord

take a look at the medical catagory
you trying to tell me thats all conspiracy?

Let the mods do the job. We can only deal with stuff when we see it. We can't see all threads all the time (how could we?). I moved your thread to the appropriate forum. I've moved other threads as well. Why are you derailing your own thread with this? Is your thread of no value to you anymore, now that it's on bts?

Well I personally hope they don't cure type 2 diabetes because it will cost me a fortune in prescription charges. I currently get all my meds for free because I'm diabetic( 2 lots of cream for psoriasis and tablets for high blood pressure,high cholesterol and aspirin to thin my blood).