The Protect Our Water Alliance (POWA), an independent, grassroots initiative, has started an online petition to urge Congress to fully investigate basic safety questions about water fluoridation, including the use of silicofluorides. The alliance was started by a group of concerned citizens from varied backgrounds to raise awareness about environmental health concerns regarding fluoride and fluorine compounds.

Using online campaigns to inform and inspire individuals and organizations around the world, POWA addresses the basis of the public policy and practice of water fluoridation. They also address other uses of fluoride and fluorine compounds that may result in environmental contamination and/or detrimental health effects.

The Union of Concerned Scientists is asking EPA administrator Stephen Johnson to reduce the Maximum Contaminant Level Goal for fluoride in drinking water from four parts per million to zero, based on the evidence of fluoride's connection to carcinogens.

In March 2006, a National Research Council panel of the National Academy of Sciences released a report of their in-depth study of fluoride toxicity, completed at the request of the EPA. The panel concluded that the current EPA safety standards for fluoride in water supplies are not protective of the safety of Americans.