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European middleweight champion Howard Eastman will meet Jerry Elliott over eight rounds on Friday.
The Briton had been set to fight Jorge Sendra, but the Spaniard was ruled out for failing to provide suitable medical evidence that he was fit to box.
"It is highly unfortunate, but in Elliott we have a competitive opponent," said promoter Mick Hennessy.
Super middleweight Carl Froch takes on Damon Hague for the British title on the same Nottingham card.