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Findings suggest that neurodegenerative disease affects other tissues and raise the possibility that heart infection could be a new aspect of prion diseases, including those that affect humans and livestock, and that these diseases could travel through the blood.
"Until now, prion disease has been thought of as a chronic neurological condition," says Scripps Research Professor Michael B. Oldstone, M.D., who led the research. "Our study has shown, however, that it can have other manifestations, therefore expanding the types of conditions it could cause."
According to the U.S. Centers for Disease Control and Prevention, the median age of death for Americans with Creutzfeldt-Jakob disease is 68, whereas the median age of death of people with new variant Creutzfeldt-Jakob in Great Britain, where most cases have occurred, is 28.
Heart Damage caused by Prion Disease Agent In Mouse Study
The Sup35p protein of Saccharomyces cerevisiae is an essential translation factor whose prion-like properties give rise to the non-Mendelian genetic element [PSI(+)]. ...These findings have important implications for ...evolution...
The Candida albicans Sup35p protein (CaSup35p): function, prion-like behaviour and an associated polyglutamine length polymorphism.
Prions ...cause a number of infectious, genetic and spontaneous disorders. ...prions (pronounced "pree-ons") multiply in an incredible way; they convert normal protein molecules into dangerous ones simply by inducing the benign molecules to change their shape.
...there are hints that the prions causing the diseases explored thus far may not be the only ones. Prions made of rather different proteins may contribute to other neurodegenerative diseases that are quite prevalent in humans. They might even participate in illnesses that attack muscles.
About 10 to 15 percent of cases are inherited, and a small number are, sadly, iatrogenic...
1995: The Prion Diseases
Patent: Milk protein biofilm and uses thereof
A biofilm for preparing laminated tissue constructs comprising at least one milk protein forming a sheet like structure can be used to support at least one layer of cells adhered to that. The biofilm allows for a easy handling of cultured cell sheets that can be used as tissue graft. The biofilm, comprising milk proteins and at least one plasticizer, when adhered by a cell layer can form a laminated tissue construct for body tissue replacement.
In recent years, outbreaks of diseases such as avian flu, severe acute respiratory syndrome (SARS), the Ebola virus, and mad cow disease have frightened the public, disrupted global commerce, caused massive economic losses, and jeopardized diplomatic relations. These diseases have also shared a worrisome key characteristic: the ability to cross the Darwinian divide between animals and people. None of these illnesses depends on human hosts for its survival; as a result, they all persist today, far beyond the reach of medical intervention.
Meanwhile, humanity has become vulnerable to cross-species illnesses,... ...diseases pay no regard to the divisions among species or academic disciplines, and the failure to recognize this truth is placing humanity in great peril. ...The obstacles to identifying, understanding, and sharing information about all infectious diseases on the planet may appear daunting. But they are no excuse for not trying. New, holistic approaches should be started...
The time to launch such initiatives is now, before the next global pandemic occurs. Bridges must be built between different scientific disciplines, and trade in wildlife must be dramatically reduced and, like the livestock industry, properly regulated. Global health will not be achieved without a philosophical shift from the expert-controlled, top-down paradigm that still dominates both science and medicine. A broader, more democratic approach is needed, one based on the understanding that there is only one world -- and only one health.
The Human-Animal Link
The USSR used it during WWII against Friedrich von Paulus's army. The Soviet government did not risk to infect fascists with plague or ulcer – they chose tularemia. Rats spread the disease in German troops very quickly. The effect was astonishing: Paulus had to take a break in his offensive on Stalingrad. According to archive documents, about 50 percent of German prisoners, who were taken captive after the battle of Stalingrad, were suffering from classic symptoms of tularemia. Unfortunately, every action leads to a counteraction. The use of infected rats against the Nazi army had an inverse effect too: the disease came over the front line, and infected a lot of Soviet soldiers.
Originally posted by thermopolis
as of late a newer more "sneaky" virus is evolving, it comes on slowly, has a brief period of "recovery" then turns the host into "jello". The infected goes from mild "flu" directly to a bleeding mass of flesh in minutes.
Originally posted by harlequin
The russians weaponised Ebola 15 years ago + - they now have chimera`d it with smallpox (on an RNA level) - ebola pox is a most horrible weapon , and tha usa has NO counter for it - there 15 years behind the russians in this area.
Did you know that the russians have 150+ tons of weaponised anthrax ready to load and use in a war?
yes the us might cry over breaches in the Biological and Toxin Weapons Convention but they have nukes , the russians have bio bombs.
btw , the russians used Bio weapons in WW2
Before 1969, when President Richard Nixon closed the American offensive biological warfare program, offensive agents were developed at the United States Army's biological-warfare laboratories at Fort Detrick, Maryland. These products, powdered spores and viruses, were loaded into bombs and other delivery systems stored at Pine Bluff, Arkansas. The 1969 budget for Chemical/Biological Warfare research was reported to be $300 million with $5 million for herbicides designed to kill food crops or strip trees of foliage to deprive enemy forces of ground cover.
...The Soviet Union, China, and North Korea accused the United States of using biological warfare against North Korea and China during the Korean War. ...Numerous unsubstantiated allegations were made during the Cold War era. These included a Soviet accusation that the United States had tested biological weapons against Canadian Eskimos, resulting in a plague epidemic, an allegation of United States plans to initiate a cholera epidemic in southeastern China, another Soviet accusation of a United States and Columbian biological attack on Columbian and Bolivian peasants.
In anticipation of the 1972 Biological Weapons Convention, President Nixon terminated the United States offensive biological weapons program by executive order. The United States adopted a policy to never use biological weapons, including toxins, under any circumstances whatsoever. National Security Decisions 35 and 44, issued during November 1969 (microorganisms) and February 1970 (toxins), mandated the cessation of offensive biological research and production, and the destruction of the biological arsenal. ...Small quantities of some pathogens were retained at Fort Detrick to test the efficacy of investigational preventive measures and therapies. [sic]
To date most "experts" have ruled ebola out as a weapon because it is too nasty. It kills too quickly and does not allow the host to spead the disease enough to sustain the chain reaction.
Distribution of this strain could be mixed with skin absorption meds like DMSO that pass through the skin directly into the bloodstream. A simple spray gun or "water pistol" become a leathal weapon of mass destruction.