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"Until now, it's been very much a single-host, single-pathogen type of framework," Rohani said. "Now with avian influenza being very much on everyone's mind, we're beginning to realize that the genetic diversity of infectious agents is really important."
RNA viruses can cause many life-threatening diseases such as hemorrhagic fevers, gastroenteritis, measles, influenza, dengue fever, encephalitis, and hepatitis.
Comparative structural genomics on viral enzymes involved in replication
The actin cytoskeleton has been implicated in playing an important role assembly and budding of several RNA virus families including retroviruses and paramyxoviruses.
Packagin g of actin into Ebola virus VLPs.
Researchers discovered that the Nipah virus, which killed 100 people last year in Singapore, originally came from fruit bats; the virus, a cousin to Ebola and HIV, is also carried by pigs
Fruit bats as reservoirs of Ebola virus.
Zoonosis is the cause of the vast majority of emerging diseases. Bats that occupy the second place in the mammal class play an important role. Whether they belong to the microchiroptera suborder or to the megachiroptera suborder, bats on all five continents have been implicated in transmission of numerous pathogens including not only viruses such as Lyssavirus (e.g. rabies), Hepanivirus (e.g. Hendra and Nipah virus) and recently coronavirus (e.g. SARS-like coronavirus and Ebola virus) but also fungus such as histoplasmosis. By modifying environmental conditions and encroaching on their biotope, human intervention has probably contributed to the introduction of chiropteras into an epidemiologic chain in which they previously had no place, thus promoting the emergence of new pathogens.
Chiropte ra and zoonosis: an emerging problem on all five continents
In December 1979, the British Medical Journal published a letter from an army physician that had laid undiscovered in a trunk in Detroit for 60 years. In the 1918 letter, the doctor who was attending to soldiers in Boston during the devastating pandemic that year described in graphic detail how they were dying from the flu: 'Two hours after admission they have the mahogany spots over the cheek bones and a few hours later you can begin to see the cyanosis extending from the ears and spreading all over the face, until it is hard to distinguish the colored man from the white.
'It is only a matter of a few hours then until death comes and it is simply a struggle for air until they suffocate.' (Cyanosis is a bluish or purplish tinge to the skin.)
Note that reports described the Sichuan patients as having skin that turned very dark. Some H5N1 bird flu variants can produce bleeding under the skin. The index case in Thailand's human cases of bird flu this year was initially misdiagnosed as dengue hemorrhagic fever because of that bleeding.
Yale Global: China Bug – Is It Ebola-like Bird Flu?
Ebola-like disease outbreak in Angola may be bird flu
Original source: Recombinomics
The youth died after being admitted to a Phichit hospital on July 20, said Thawat Suntrajarn, director general of the ministry's disease control department, in a telephone interview today.
He tested positive to both dengue hemorrhagic fever and H5N1 avian flu, Thawat said.
112 people in Thailand under watch for bird flu
Authorities admit return of bird flu
As of June 17, there had been about 12,500 cases of dengue fever reported across Thailand this year or about 20 per 100,000 people. The total number of deaths from dengue fever in the period was 15.
Thailand on high alert for dengue outbreak
Dengue fever warning issued for south
Four provinces in Thailand declared "red zones" for dengue
Originally posted by Valhall
I have to say I'm actually surprised the combination hasn't occurred yet.
The world is now in the gravest possible danger of a pandemic. If the virus becomes highly contagious among humans, the health impact in terms of deaths and sickness will be enormous" - Shigeru Omi (WHO)
We are seeing a highly pathogenic strain of influenza virus emerge ... across the entire western component of Asia. You may see the emergence of a new strain to which the human population has no immunity. - Dr. Julie Gerberding (head of US Center of Disease Control and Prevention)
"For a virus to completely redesign itself to become a more efficiently transmitted virus, that's going to take time," she said. "It's a race between us and the virus, and we hope we win."
CDC puts genetic sequences of about 40 human H5N1 viruses into public domain
The move to put the data in the public domain, giving scientists from around the world free access, came after the Indonesian government told the World Health Organization on Thursday that it was willing to share the genetic sequences of all H5N1 viruses isolated from humans there.
The CDC's influenza division is a reference laboratory for the WHO. The CDC and a laboratory at the University of Hong Kong run by influenza authority Dr. Malik Peiris have sequenced the human H5N1 viruses from Indonesia for the WHO. Peiris has also been asked by the WHO to release the Indonesian data in his possession. ...On Friday, CDC staff transferred genetic codes of more than 300 individual H5N1 genes into an open access sequence bank called the Influenza Sequence Database. Cox said the data will also be logged into Genbank, a second open access database. ...The Influenza Sequence Database is housed by the U.S. Department of Energy's Los Alamos National Laboratory; the same computers host a password-protected WHO database that includes the sequences of all H5N1 viruses that have been turned over to the WHO system.
That limited access system has been harshly criticized by scientists who don't have access to it. They have complained that keeping the data sequestered in this way is impeding the global scientific community's ability to puzzle out the mysteries of this dangerous virus.