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Originally posted by Jazzerman
Thanks for the information. I don't know why my agency does not have a subscription to Vaccine, as I think it is an excellent resource to not only physicians but members of the general public.
I'm with you on this one, and it never dawned on me that Transactivating Regulatory proteins could be used in the development of a general vaccine to cover all the genetic mutations of HIV since it was first known about back in 1985. Because these particular proteins are essential for the viral replication process which leads to the conversion of virion RNA into DNA, I think as you, that this is one possible way to an effective vaccine. However, I have yet to see any effective drug trial for such a procedure, and in lieu of this, do you know of any further trials that were effectively done as the last one I heard about was back around 2002 when some Italian lab was going to start trials, or the one done with Rhesus monkeys that were immunized with the inactivated protein?
Also, I am not 100% convinced that an effective vaccine cannot be produced with proteins on the viral envelope or for that matter from REV, NEF, VPR, Group specific Antigens, or the like (to numerous to go over every one).
Originally posted by bsl4doc
Another interesting point, however, is that a new drug just came out which is VERY promising for currently HIV+ patients. It's actually a combo drug, and is called Atripla...I think it's great that they combined these pills into a once-a-day dosage, as that makes it much more unlikely that patients will miss a dose.
Originally posted by ATSGUY
How long do you think it will take to establish if this will work, i heard scientist say that we are only a few years 5-10 years away from a vaccine.