We already know that TOBI is effective in chronic infection, and recent evidence suggests ... TOBI is inhaled twice daily, for about 15 minutes each
Tobi is now a year old and he has three issues that are driving me crazy. Despite numerous efforts, he is still not poddie trained. ...
ToBI is a framework for developing community-wide conventions for transcribing the ... Note: ToBI is not an International Phonetic Alphabet for
1. What type of equipment should be used for administration of TOBI?
TOBI should be administered using a PARI LC PLUS Reusable Nebulizer and DeVilbiss Pulmo-Aide air compressor. The results of the TOBI clinical studies
were obtained using this equipment. No other types of equipment have been tested with TOBI, and therefore, the use of other equipment may affect
safety, efficacy and treatment time.
2. Why was the PARI LC PLUS Reusable Nebulizer and the DeVilbiss Pulmo-Aide air compressor chosen for your clinical studies?
The PARI LC PLUS was chosen based on a comparison of three different nebulizers in an earlier trial. The DeVilbiss Pulmo-Aide was chosen because it is
commonly used by CF patients to administer other medications and therefore, they are likely to be familiar with it.
3. Can TOBI be mixed with other inhaled medications?
No, TOBI should not be diluted or mixed in the nebulizer with any other medications, including dornase alfa (PULMOZYME®, Genentech). TOBI should not
be diluted with water or saline. Mixing TOBI with other drugs in the same nebulizer has not been studied.
4. How should TOBI be stored?
Patients should store TOBI ampules in a refrigerator (2-8°C or 36-46°F). However, when a refrigerator is not available, for example when
transporting TOBI, you may store the foil pouches (opened or unopened) for up to 28 days at room temperature not exceeding 25°C or 77°F.
Unrefrigerated TOBI, which is normally slightly yellow, may darken with age; however, the color change does not indicate any change in the quality of
5. My TOBI has a yellow color. Is it still OK to use?
TOBI is clear and slightly yellow. As you become familiar with it, you will notice that there is a slight change in TOBI's color, from light yellow
to a darker yellow. This is normal as the drug ages, or as changes in temperature or exposure to light occur. When TOBI is exposed to intense light,
it will change color from light to dark yellow at a faster rate, and my eventually become brown with prolonged exposure. The color change does not
indicate any change in the quality of the product as long as it has been stored as recommended.
TOBI is still safe to use as it changes color as long as:
1. there are no particles floating in the solution;
2. it is not cloudy;
3. the drug has not been out of refrigeration at room temperature for more than 28 days; and
4. the expiration date has not passed.
6. How safe is TOBI?
The safety of TOBI for treating CF patients was one of the main questions to be answered in our studies. TOBI is in a class of drugs that, when given
intravenously, has caused hearing loss, dizziness, kidney damage, and harm to a fetus. Therefore, we wanted to make sure that TOBI would be safe when
given by inhalation. We looked at reports of side effects and at lab analyses of patients' blood, and we performed physical exams during certain
planned visits to the clinic. We found TOBI was generally well tolerated by CF patients in our studies, although ringing in the ears and hoarseness
were two symptoms that were seen in more patients taking TOBI than placebo.
If you have additional questions about the safety of TOBI, please consult the full prescribing information and your physician.
7. I'm a patient taking a bronchodilator, dornase alfa (PULMOZYME®), inhaled steroids, and TOBI. In what order should each be administered?
During our clinical trials, patients on several therapies were instructed to administer therapies in the following order: bronchodilator first,
followed by chest physiotherapy (PT), then other inhaled drugs, and finally TOBI. Ask your physician what would be the best treatment regimen for
8. TOBI tastes bad. Is there anything you can do to change the taste?
Due to its chemical structure, the active ingredient in TOBI, tobramycin, has been associated with a bitter taste and/or an unpleasant odor. To help
the smell and taste, some patients have used nose clips while administering TOBI, and they have tried sucking on a lemon drop, mint or cherry flavored
mouthwash afterwards. Most patients do get used to the taste after they have taken TOBI for a while.
9. What are the differences between TOBI and intravenous solutions of tobramycin used for inhalation?
TOBI is the only tobramycin solution approved by the Food and Drug Administration (FDA) for inhalation in CF patients. The FDA has not approved the
safety and efficacy of inhaling IV solutions of tobramycin or mixing solutions at home for chronic use. In addition, TOBI is preservative-free and is
specifically formulated for inhalation. TOBI is available in single dose, ready-to-use ampules containing the recommended dose of 300 mg of
For more information on how to take TOBI, please consult the full prescribing information and your physician.
then apparently there is a homoerotic film where the lead chr is named tobi
And although Tobi is curious about these rowers, even eavesdropping on their conversations, he is also afraid of his homosexuality being exposed.
that still has me laughing
it gets gayer
Tobi is very special to me and my family, but since the hurricanes pounded ... Tobi is the most beautiful bunny on the planet and I want most of all
to save ...
I say they eat me.
[edit on 5-4-2006 by Lysergic]