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Eleven patients have died while taking Alzheimer's disease drug Aricept during a clinical trial, Japan's Eisai Co., which makes the medicine, said Thursday. ...There were no deaths among patients who were taking a placebo, said Eisai, which markets Aricept with Pfizer Inc.
The drug, which treats mild to moderate Alzheimer's disease, was being tested in patients with vascular dementia, the second most common form of dementia after Alzheimer's disease. ...Applications to expand the use of Aricept to vascular dementia, which is caused by a stroke or diseased blood vessels, are pending in both the United States and Europe, said Eisai spokeswoman Judee Shuler.
Shuler said she could not comment on how the results might affect the status of Aricept.
Originally posted by DaFunk13
On topic though, these people were well aware of the risks when the signed up for the trial.
An unusual number of deaths among patients in a large study of Aricept, the most popular drug to treat Alzheimer's disease, is raising concern among federal drug officials and some disease experts. ...In the study, of 974 patients who suffered from dementia related to heart disease, 11 deaths occurred among the patients taking Aricept, while no deaths occurred among those taking dummy pills.
...experts in Alzheimer's disease said that the new study should not be dismissed and that it might indicate that Aricept and similar drugs increased the risks of heart disease. Because Aricept's benefits in fighting Alzheimer's disease are at best mild, any increase in risk should cause concern, they said. ..."These drugs are well known to slow the heart and constrict the respiratory passage ways," said Dr. Lon Schneider, a professor of psychiatry, neurology and gerontology at the University of Southern California.
...The study's results are similar to those of a study done some years ago on Reminyl, made by Johnson & Johnson, a drug similar to Aricept. In that study, 2,000 patients with early signs of Alzheimer's disease were followed for two years. Far more of the patients given Reminyl died than did those who received placebos, Dr. Schneider said.
Even before this latest news, many physicians recommended against giving Aricept, Reminyl, Exelon and Tacrine — which all act similarly — to Alzheimer's patients because they believed that the drugs did not provide enough benefit to merit their expense or risks. ...A British study last year found that therapy with Aricept does not delay the onset of disability or the need for nursing home care. The researchers concluded that Aricept had "disappointingly little overall benefit" and was not cost-effective.
Originally posted by DaFunk13
On topic though, these people were well aware of the risks when the signed up for the trial. The mice and chimps did not.
Elderly couple at the airport meeting the grandchildren who come running up to them.
"Debbie?" The old man says
Close up of adorable little girl, crestfallen, face screwed into a terrible grimace, apparently near tears looks upon her grandfather, frightened and as if he is a stranger...
"I'm Julie" she wails pitifully looking up toward grandmother for some explanation of this horror.
Grandmother clearly embarrassed.
Looks like she wishes she didn't know the poor old guy. Who stands there looking deranged and dangerous - much like a "child molester".