Is Bird Flu Killing All Those Whales?, page 1
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Topic started on 20-2-2006 @ 09:42 AM by soficrow
We're seeing yet another round of mysterious whale deaths. Supposedly, these deaths cannot be explained.


Mexican authorities are investigating the mysterious deaths of eight whales found washed ashore along the Sea of Cortez last month, an unusually large number that suggests someone or something is killing them off.

The whales come from several plankton-eating species and apparently died at sea in November and December, biologists said. But they do not show any signs of having been caught in long-line fishing nets, which sometimes suffocate the mammoth animals. Nor have biologists found any signs of a toxic spill or outbreak of disease that would account for their deaths.

"Right now it's a mystery," said Luis Fueyo, an assistant federal prosecutor for environmental crimes, who is overseeing the investigation. "We have a puzzle." ...The investigators also looked for signs of disease or poisons, both natural and synthetic. It was slow going. All of the bodies were badly decomposed. Only the baby gray whale provided enough tissue to test for diseases or poisons. ...On Friday, environmental officials announced that those tests had found no evidence of a toxic algae bloom, other poisons or infections. Nor have the investigations turned up signs of mistreatment by fishermen.

What's Killing All Those Whales?



However, H5N1 bird flu is a Type A virus, which can infect whales.

As stated in the February 2004 WHO Report on H5N1: "Several studies have shown that a small number of mammalian species, including pigs, seals, whales, mink, and ferrets, are susceptible to natural infection with influenza viruses that are purely avian in their genetic make-up." The Mayo Clinic reports, "type A influenza infects both people and animals, including birds, pigs, horses, whales and seals."

Also see: "Bird Flu: Why Worry Now?"


Viruses can be "vehicles of prion transmission."


Prion diseases are unique in that they can be inherited, they can occur sporadically, and they can be infectious. The infectious agent in the prion disease is composed mainly or entirely of an abnormal conformation of a host-encoded glycoprotein called the prion protein.

The transmission of this disease (scrapie) was demonstrated first in 1943 when a population of Scottish sheep was accidentally inoculated against a common virus using a formalin extract of lymphoid tissue from an animal with scrapie (Gordon, 1946). Accidental transmission of prions is a recurrent event in the history of these agents and is related to their unusual biophysical properties.

Prion Related Diseases

***

This 1986 paper describes how "proteinaceous capsids" (prions) use viruses as vehicles of transmission...
* "Viral influences on aflatoxin formation by Aspergillus flavus." Appl Microbiol Biotechnol 24:248-252. Schmidt FR, Lemke PA, Esser K (1986)

"Epidemiological observations indicate that a microbial vector is responsible for the transmission of natural prion disease in sheep and goats … ...It is proposed that many microbial proteins may be capable of replicating themselves in mammalian cells eliciting and sustaining thereby degenerative and/or autoimmune reactions subsequent to infections with microorganisms."
* Is the pathogen of prion disease a microbial protein? Med Hypotheses. 1999 Aug;53(2):91-102. Fuzi M. Budapest Institute of National Public Health and Medical Officer Service, Hungary. PMID: 10532698

* Dangerous liaisons between a microbe and the prion protein. J Exp Med. 2003 Jul 7;198(1):1-4. Aguzzi A, Hardt WD. PMID: 12847133




Especially important, H5N1 bird flu carries a misfolded protein called "a-smooth muscle actin" (ASMA). ASMA creates abnormal myofibroblasts, which in turn cause "abnormal wound healing" and "tissue remodeling" in connective tissue and smooth muscle. The lungs, fat cells and digestive tract are especially vulnerable.

If, as the evidence suggests, the main culprit in H5N1 bird flu is not the virus itself, but rather a prion hitchhiker - then a vaccine would simply spread the disease.

In my opinion, the public has a right to be fully informed - and a right to be given the real information. And I have questions:

Is H5N1 "bird flu" spreading through the planet's animal kingdom? Is it partly responsible for the current rates of extinction?

Is H5N1 "bird flu" - and its prion hitchhiker - already responsible for the world's chronic disease epidemic in humans?

What is the real hold up on getting a human vaccine for H5N1 bird flu?






Also see:

The H5N1 avian influenza virus can survive for more than a month in bird droppings in cold weather and for nearly a week even in hot summer temperatures, the World Health Organization said on Friday.

Rats, flies likely to spread avian influenza


Animal prion infections, such as scrapie (sheep) and "mad cow disease" (cattle), have shown a pattern of horizontal transmission in farm conditions and several ectoparasites have been shown to harbor prion rods in laboratory experiments. Fly larvae and mites were exposed to brain-infected material and were readily able to transmit scrapie to hamsters. New lines of evidence have confirmed that adult flies are also able to express prion proteins. ...Several cell types found on the human skin, including keratinocytes, fibroblasts and lymphocytes, are susceptible to the abnormal infective isoform of the prion protein, which transforms the skin to produce a potential target for prion infection.

Could ectoparasites act as vectors for prion diseases? Int J Dermatol. 2003 Jun;42(6):425-9. Lupi O. Center for Vaccine Development, University of Texas Medical Branch at Galveston, Galveston, TX, USA. PMID: 12786866



Prion transmission in blood and urine



[edit on 20-2-2006 by soficrow]
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