Very interesting stuff. Thanks everyone.
...So I woke up this morning, went into my files, and wrote this.
Dorlands (quoted above) says "exogenous or endogenous protein" can cause the hypersensitivity reaction in leukocytoclastic vasculitis. Dorland's
reference to proteins raises the specter of prions. So here we go again...
Many drugs are known to create misfolded proteins that then become infectious prions inside the body. In my case, an allergic reaction to penicillin
at the age of five created a prion called "a-smooth muscle actin" (ASMA), which then infected my blood vessels. In my late teens, my doctor decided
I was not really
allergic to penicillin, saying, as I recall, that I was "only hypersensitive." He treated me weekly with penicillin
injections for "chronic bronchitis" - until I went into anaphylactic shock and a coma from the "treatment." These exposures resulted in my
acquiring an incurable and now untreatable disease called fibromuscular dysplasia (FMD). (1)
FMD is one of a large group of diseases that involve ASMA. In fact, FMD appears to be one stage of the disease process where ASMA uses the vascular
and immune systems to spread through the body.
Notably, Fibromuscular dysplasia (FMD) is
one of the most important mimics of vasculitis.
Also see "About primary systemic vasculitis" below.
The important information:
1. Drugs, including prescription medications, can create misfolded proteins, which cause hypersensitive or allergic reactions.
2. The misfolded proteins can become infectious prions and spread through the body.
3. The "hypersensitive response" can involve blood vessel walls, organs, lungs, skin, and more.
4. Once created, these artificial infectious prions don't die because they are not alive; they may become 'inactive,' but retain the ability to
replicate on contact
with similarly shaped healthy proteins, by transforming them.
5. Infectious prions can be passed on congenitally, and may cause birth defects or genetic mutations.
6. Infectious prions can be transmitted via urine and other bodily excretions, and have the ability to mutate into new strains on exposure to
differently shaped proteins, or environmental change.
7. While allergic reactions to medications and other drugs are not the only
way infectious prions are created, the process is both known and
IMPORTANT NOTE: Although infectious prions can't die, and they replicate by transforming healthy proteins on contact, the reverse also is true - they
also can be transformed from their infectious shape into a healthy state when they are outnumbered.
Stem cell therapy is the only treatment
that can provide enough healthy proteins to outnumber infectious prions in the body, and do so without creating new prion strains.
1. Vascular Effects of Penicillin Allergy
1954 - "A case of vascular-spastic penicillin allergy." Z Arztl Fortbild (Jena). 1954 Dec 15;48(23-24):810-11. KRAUSE I. PMID: 14360179
1981 - Dtsch Med Wochenschr. 1981 Nov 13;106(46):1541-4. [Arterial vascular occlusion in penicillin allergy (author's transl)] Martin M, Becker M,
Adjodani B, Zeitler E, Havers L. PMID: 6796371
2. Primary Systemic Vasculitis:
"Although hypersensitivity vasculitis is occasionally idiopathic, there are multiple known etiologies, including medications, infections, malignancy
and primary connective tissue diseases.
As described by Mandell and Hoffman,1 vasculitis-induced injury to blood vessels may lead to increased vascular permeability, vessel weakening that
causes aneurysm formation or hemorrhage, and intimal proliferation and thrombosis that result in obstruction and local ischemia. Because systemic
vasculitis can affect vessels of all sizes and distributions, it has a wide spectrum of clinical features. Knowing the size of the vessels affected in
a particular patient is important, since vessel size carries implications for the diagnosis, treatment and prognosis of the disease (Table 1)."
- inflammation of a blood or lymph vessel; see arteritis, lymphangitis, and phlebitis. Called also angiitis.