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Antimicrob Agents Chemother. 2005 Nov;49(11):4789-92. Therapeutic Effects of Bacteriophage Cpl-1 Lysin against Streptococcus pneumoniae Endocarditis in Rats. Entenza JM, Loeffler JM, Grandgirard D, Fischetti VA, Moreillon P. Department of Fundamental Microbiology, Biology Building, University of Lausanne, CH-1015 Lausanne, Switzerland. Jose.Entenza@unil.ch.
Cpl-1, a pneumococcal phage lytic enzyme, was tested in rats with experimental endocarditis due to Streptococcus pneumoniae WB4. High-dose regimen Cpl-1 eliminated pneumococci from blood within 30 min and decreased bacterial titers in vegetations (>4 log(10) CFU/g) within 2 h. Rapid bacterial lysis induced by Cpl-1 treatment increased cytokine secretion noticeably.
Monday, October 31, 2005. Phages: A New Way to Fight Bad Germs
Back in June I was amazed at this story in Wired about phages, bacteria-eating viruses that could be the answer to antibiotic resistance. The first treatment to use the therapy could be available this year.
"Half a century ago, antibiotics revolutionized medicine by turning many once-deadly infections like tuberculosis into minor impediments. But overuse is rapidly rendering antibiotics ineffective, and scientists know they need a replacement fast. One of the most promising options is one that's been used in Eastern Europe and Russia for decades: bacteriophage therapy
One potential drawback is that phage therapies might be too specific for widespread use against infection, according to Carl Merril, a senior investigator at the National Institutes of Health. For example, one phage might work for one strain of Streptococcus pneumoniae (the most common type of pneumonia) but not for the 27 others.
More interesting background: THE VIRUS THAT CURES
* At a press conference on May 23rd 1997 scientists finally acknowledged the arrival of the untreatable bacteria they'd feared for years.
Today superbugs look triumphant. They are bacteria that resist our antibiotics. The drugs which have kept us safe for 50 years are beginning to fail.
DR GLENN MORRIS:
This is a serious situation. Over the last 5 years we've clearly seen a change in our ability to treat what should have been easily treatable infections because the bacteria have developed the ability of resisting the antibiotics.
And the more antibiotics we use, the more resistant bacteria become. Every year more than 5 million people die from infections that don't respond to antibiotics.
These horrifying bacteria have colonised hundreds of hospitals in Britain, and thousands in the USA. And things are going to get worse. Staphylococcus is one of the most dangerous of all bacteria. One by one it has beaten all our best antibiotics. Until now only one is left - vancomycin.
Originally posted by Long Lance
that's such an elegant, straight to the point and, *gasp* easy way to do it.
our culture is far too obsessed with overly complicated solutions, it's a shame, isn't it? btw, voted you 'way above'.
Originally posted by soficrow
...Cool thing is, phages evolve and mutate right along with the bacteria - so the bacteria can't become resistant.
BTW - I assume viruses and other microbes have natural predators too, but haven't found anything on it. Have you? Anyone else?
Originally posted by mattison0922
Sofi - Great Post. I have long been a proponent of alternatives to Antibiotic therapy. ...your point about mutating is well taken, though bacteria are less likely to become resistant to phages, since phages don't target specific biochemical systems.