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Earlier this summer, the Summit supercomputer at Oak Ridge National Lab in Tennessee set about crunching data on more than 40,000 genes from 17,000 genetic samples in an effort to better understand Covid-19. Summit is the second-fastest computer in the world, but the process — which involved analyzing 2.5 billion genetic combinations — still took more than a week.
When Summit was done, researchers analyzed the results. It was, in the words of Dr. Daniel Jacobson, lead researcher and chief scientist for computational systems biology at Oak Ridge, a “eureka moment.” The computer had revealed a new theory about how Covid-19 impacts the body: the bradykinin hypothesis. The hypothesis provides a model that explains many aspects of Covid-19, including some of its most bizarre symptoms. It also suggests 10-plus potential treatments, many of which are already FDA approved. Jacobson’s group published their results in a paper in the journal eLife in early July.
As bradykinin builds up in the body, it dramatically increases vascular permeability. In short, it makes your blood vessels leaky. This aligns with recent clinical data, which increasingly views Covid-19 primarily as a vascular disease, rather than a respiratory one. But Covid-19 still has a massive effect on the lungs. As blood vessels start to leak due to a bradykinin storm, the researchers say, the lungs can fill with fluid. Immune cells also leak out into the lungs, Jacobson’s team found, causing inflammation.
And Covid-19 has another especially insidious trick. Through another pathway, the team’s data shows, it increases production of hyaluronic acid (HLA) in the lungs. HLA is often used in soaps and lotions for its ability to absorb more than 1,000 times its weight in fluid. When it combines with fluid leaking into the lungs, the results are disastrous: It forms a hydrogel, which can fill the lungs in some patients. According to Jacobson, once this happens, “it’s like trying to breathe through Jell-O.”
The bradykinin hypothesis also accounts for Covid-19’s neurological effects, which are some of the most surprising and concerning elements of the disease. These symptoms (which include dizziness, seizures, delirium, and stroke) are present in as many as half of hospitalized Covid-19 patients. According to Jacobson and his team, MRI studies in France revealed that many Covid-19 patients have evidence of leaky blood vessels in their brains.
Bradykinin — especially at high doses — can also lead to a breakdown of the blood-brain barrier. Under normal circumstances, this barrier acts as a filter between your brain and the rest of your circulatory system. It lets in the nutrients and small molecules that the brain needs to function, while keeping out toxins and pathogens and keeping the brain’s internal environment tightly regulated.
originally posted by: trollz
I only skimmed over this, but does this new finding suggest anything about whether Covid-19 was naturally-occurring, or intentionally modified, or even a weapon?
originally posted by: trollz
I only skimmed over this, but does this new finding suggest anything about whether Covid-19 was naturally-occurring, or intentionally modified, or even a weapon?
originally posted by: trollz
I only skimmed over this, but does this new finding suggest anything about whether Covid-19 was naturally-occurring, or intentionally modified, or even a weapon?
originally posted by: randomthoughts12
a reply to: HalWesten
This would make perfect sense as to why things like ibuprofen don't help. I'm assuming any blood thinner wouldn't help but only make it worse.
originally posted by: PhyllidaDavenport
a reply to: ketsuko
It could still have been a weapon, only not a weapon to annihilate the population...only the world's economies leaving the door open for China to rush in to "save" all these bankrupt businesses. This has become quite a talking point across the planet enough to force some countries to ban China from take overs & investment.
See China's 100yr plan for further info
WIP got out by accident much earlier than planned!
originally posted by: PhyllidaDavenport
a reply to: ketsuko
It could still have been a weapon, only not a weapon to annihilate the population...only the world's economies leaving the door open for China to rush in to "save" all these bankrupt businesses. This has become quite a talking point across the planet enough to force some countries to ban China from take overs & investment.
See China's 100yr plan for further info
originally posted by: rickymouse I get cytokine storms from the flu vaccine, or something like it anyway, they make me sick and sore as hell. I am kind of cautious about taking this new vaccine, my body might over react to it like it does to the flu and pertusis vaccines.