Note the statistics from this study that compares Methylprednisolone (included in the MATH+ protocol that the EVMS is using for example),
Dexamethasone, Hydrocortisone and Prednisone (in the steroid category, they have more categories). Note in table 2 their results have Hydrocortisone
as the worst treatment (deepest in the red of all those steroids, meaning it makes things worse for the patient than not getting that medication).
Prednisone is the only one in the green. Dexamethasone and Hydrocortisone are in the red. Methylprednisolone is somewhere in the middle.
Observational Study of the Efficiency of Treatments in Patients
Hospitalized with Covid-19 in Madrid (pdf)
Just for a quick comparison, I'll quote the hazard ratios before and after propensity-score matching. "Negative d or hazard ratio less than 1 implies
patients treated with that medication died less than those that did not. The opposite is true for positive d or >1 hazard ratio. Medications
highlighted in red have at least a small positive d (>0.2) after propensity-score matching. Similarly, medications highlighted in green have d <
-0.2." (says the description under that table there)
Methylprednisolone: 1.11; after propensity-score matching: 1.01
Dexamethasone: 1.26; 1.12
Hydrocortisone: 1.44 ; 1.30
Prednisone: 0.94; 0.85
Notice how far hydrocortisone sticks out from the rest in a negative direction, even after propensity-score matching. Remember, these are
immunosuppressors that have the side-effect of constricting blood vessels. Blood clotting is an issue in Covid-19. Suppressing your immune-system, is
quite a drastic risky measure. There may be less invasive methods, see for example their category called "Immunomodulators" in the same table with
HCQ's hazard ratio listed at: 0.79 before propensity-score matching. Even better than prednisone.
Note that these immunosuppressors (the corticosteroids) have no effect on viral reduction, unlike HCQ + Azithromycin + zinc + vitamin C (the first 3
stalling or inhibiting viral replication, that is, the latter 2 primarily only in combination with HCQ, HCQ is the only one that can do it fairly
effectively on its own but not nearly as effective as with all 3 substances, HCQ can also inhibit viral entry into the cell, and vitamin C is involved
in getting rid of the virus). Not to overlook the immunomodulating functions of HCQ in regards to Interleukin 6 and the cytokine storm, but I figured
that should be obvious from how they categorized HCQ in that table.
Also not to forget about vitamin D3 for its immunomodulating effects, but my point was about immunosuppressors (the corticosteroids) having no effect
on viral reduction. Early treatment focussed on viral reduction is still key in the treatment of Covid-19 as well as the corona virus pandemic (less
viral load is also less spread, or viral shedding*).
The term is used to refer to shedding from a single cell, shedding from one part of the body into another part of the body, and shedding from
bodies into the environment where the viruses may infect other bodies."
Source: Viral shedding - Wikipedia
edit on 3-9-2020 by whereislogic because: (no reason