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The researchers decided to conduct their experiments on a human lung cell line called Calu-3 to find out whether chloroquine has the same inhibitory effect here. After all, the novel coronavirus mainly finds its way into the human body via the lungs.
"The virus docks on the cell in the lung, is then activated by the protease TMPRSS2 and can thus enter the cell," explains Hoffmann. While chloroquine shows an inhibitory effect in the monkey cell model, it has no effect on the protease in human lung cells. "Here, it was shown that chloroquine does not prevent the virus from entering the cells," said Pöhlmann.
An abundance of evidence has accumulated over the past 50 y to demonstrate the antiviral activity of zinc against a variety of viruses, and via numerous mechanisms. The therapeutic use of zinc for viral infections such as herpes simplex virus and the common cold has stemmed from these findings; however, there remains much to be learned regarding the antiviral mechanisms and clinical benefit of zinc supplementation as a preventative and therapeutic treatment for viral infections.
The present study investigated the interaction of zinc ions with chloroquine in a human ovarian cancer cell line (A2780). Chloroquine enhanced zinc uptake by A2780 cells in a concentration-dependent manner, as assayed using a fluorescent zinc probe. This enhancement was attenuated by TPEN, a high affinity metal-binding compound, indicating the specificity of the zinc uptake. Furthermore, addition of copper or iron ions had no effect on chloroquine-induced zinc uptake.
Again, read the paper
Why on earth would I attempt to interpret that Redneck?
They are reporting the truth for each component study - BUT - You're not connecting the dots.
hydroxychloroquine on its own doesn't work against covid-19 and immune system reactions
azithromycin on its own doesn't work against covid-19 and immune system reactions but helps fight bacterial infection
zinc on its own doesn't work well against covid-19 and immune system reactions
What conclusive study is there to demonstrate that Zinc alongside HCQ is an effective treatment against Covid19?
I agree with the statement from Dr. Steven Hahn, Commissioner of the Food and Drug Administration, that the decision about prescribing hydroxychloroquine to treat COVID-19 should be between a doctor and a patient,” DeWine said in a statement. “Therefore, I am asking the Ohio Board of Pharmacy to halt their new rule prohibiting the selling or dispensing of hydroxychloroquine or chloroquine for the treatment or prevention of COVID-19.”
What conclusive study is there to demonstrate that Zinc alongside HCQ is not an effective treatment against Covid19?
Explanation: Once again we are dealing with confusion of probability and possibility. The inability to, “prove”, in any sense of the word, that the ghost of Elvis is not visiting Sheila in her dreams is an impossible request because there is no test that proves the existence and presence of a ghost, so no way to prove the negative or the non-existence. It is up to Sheila to provide proof of this claim, or at least acknowledge that actually being visited by Elvis’ ghost is just a possibility, no matter how slim that possibility is.
Prescriptions for either presumptive positive patients or prophylactic use of chloroquine or hydroxychloroquine related to COVID-19 is strictly prohibited unless otherwise approved by the board's executive director in consultation with the board president,at which time a resolution shall issue.
The ball is still very much in your court.
It's very telling how the game is played by posters here. Nothing showing that HCQ is a proper treatment to COVID19, insist there was missing ingredient that was conveniently left out before. Asked if there's any demonstration of that effectiveness, lean right back to making fallacious excuses.
I've heard that the oil of snakes can be an effective treatment for anything and everything that ails you.
It's also not poisonous. No risks involved at all. So what's the problem? It might save lives.
Bureaucratic bull#, indeed.
Why can't you do the same with hydroxychloroquine, azithromycin, and zinc in combination taken at the onset of symptoms?
Yes, it is very telling. You just in the last page admitted you ignore reports and instead rely on talking heads,