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originally posted by: Blue Shift
The biggest problem, as always, is that "God" is completely undefined. It has no definition that doesn't inherently carry with it a nullifying paradox or contradiction, making it utterly useless as an explanation for anything (or everything).
Try it. Come up with one. Define God. See if you can do better than 7,000 years of religion and philosophy. I'd be curious to see what you come up with that could be a reasonable, useful explanation for something.
Abstract
Many RNAs do not directly code proteins but are nonetheless indispensable to cellular function. These strands fold into intricate three-dimensional shapes that are essential structures in protein synthesis, splicing, and many other processes of gene regulation and expression. A variety of biophysical and biochemical methods are now showing, in real time, how ribosomal subunits and other ribonucleoprotein complexes assemble from their molecular components. Footprinting methods are particularly useful for studying the folding of long RNAs: they provide quantitative information about the conformational state of each residue and require little material. Data from footprinting complement the global information available from small-angle X-ray scattering or cryo-electron microscopy, as well as the dynamic information derived from single-molecule Förster resonance energy transfer (FRET) and NMR methods. In this Account, I discuss how we have used hydroxyl radical footprinting and other experimental methods to study pathways of RNA folding and 30S ribosome assembly. Hydroxyl radical footprinting probes the solvent accessibility of the RNA backbone at each residue in as little as 10 ms, providing detailed views of RNA folding pathways in real time. In conjunction with other methods such as solution scattering and single-molecule FRET, time-resolved footprinting of ribozymes showed that stable domains of RNA tertiary structure fold in less than 1 s. However, the free energy landscapes for RNA folding are rugged, and individual molecules kinetically partition into folding pathways that lead through metastable intermediates, stalling the folding or assembly process. Time-resolved footprinting was used to follow the formation of tertiary structure and protein interactions in the 16S ribosomal RNA (rRNA) during the assembly of 30S ribosomes. As previously observed in much simpler ribozymes, assembly occurs in stages, with individual molecules taking different routes to the final complex. Interactions occur concurrently in all domains of the 16S rRNA, and multistage protection of binding sites of individual proteins suggests that initial encounter complexes between the rRNA and ribosomal proteins are remodeled during assembly. Equilibrium footprinting experiments showed that one primary binding protein was sufficient to stabilize the tertiary structure of the entire 16S 5'-domain. The rich detail available from the footprinting data showed that the secondary assembly protein S16 suppresses non-native structures in the 16S 5'-domain. In doing so, S16 enables a conformational switch distant from its own binding site, which may play a role in establishing interactions with other domains of the 30S subunit. Together, the footprinting results show how protein-induced changes in RNA structure are communicated over long distances, ensuring cooperative assembly of even very large RNA-protein complexes such as the ribosome.
originally posted by: rom12345
originally posted by: Blue Shift
The biggest problem, as always, is that "God" is completely undefined. It has no definition that doesn't inherently carry with it a nullifying paradox or contradiction, making it utterly useless as an explanation for anything (or everything).
Try it. Come up with one. Define God. See if you can do better than 7,000 years of religion and philosophy. I'd be curious to see what you come up with that could be a reasonable, useful explanation for something.
You can only define God in terms of what he is not.
I would say that God as I understand, is the only thing to exists, as the substate and a cause of all properties to come in to existence, including the human phenomena of intelligence. The paradox of enumeration is an illusion.
originally posted by: dffrntkndfnml
originally posted by: neoholographic
a reply to: a325nt
Tell me:
How did a series of random events encode sequence with information and also build the machinery to decode that sequence?
How did random events evolve parts that just happen to be the right size, shape and come together at the right angles to build things like molecular machines with 50 different parts?
This isn't about a gap in knowledge. Tell me how this is possible for randomness to achieve. Tell me how a medium can encode itself with information and build the machinery to decode this information without intelligence.
Waiting........
Interesting thread neoholographic, makes one pause and think.
Idk, how it could be possible.
Looking back I always suspected an intelligence at work, even if it felt incredibly vague.
I often got the impression while exploring this area with others in more materially-minded debates, that intelligence arose as the byproduct of natural evolutionary forces at work. Intelligence as a reflection of a particular form of order. Time being the medium for consciousness to evolve.
Imo, the more we are learning about the world around us the greater the suspicions that higher intelligence is at work on every scale. A more fractal perspective of the universe. Brings to mind timewave zero and the singularity.
In a material sense, I build things at work. If I carry on where something was left off, I can often walk into the area, study the work and continue by carrying on further over. With experience, it can become second nature.
Most often though, you study the prints and go from there. Intelligence preceding action in either case.
originally posted by: rom12345
God is the voice in peoples heads, that make them emerge from caves and build civilization.
The utility of which is yet to be revealed.