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originally posted by: McGinty
a reply to: Serdgiam
...
However, I’m just as bad with the proliferation of supplements I’m now consuming to try and protect myself from the virus (around 11 different pills p/day) without any real knowledge regarding their dose, effects and relationships with each other. But I need to put up a fight of some kind - to be proactive rather than simply hope for the best.
originally posted by: whereislogic
originally posted by: McGinty
a reply to: Serdgiam
...
However, I’m just as bad with the proliferation of supplements I’m now consuming to try and protect myself from the virus (around 11 different pills p/day) without any real knowledge regarding their dose, effects and relationships with each other. But I need to put up a fight of some kind - to be proactive rather than simply hope for the best.
You can probably cut that down a little, regarding supplements, these are the most important in relation to Covid-19:
Quercetin (especially if you can't get HCQ, otherwise it's less important; effects or functions: it binds with the ACE2 receptor, keeping it occupied so that the coronavirus can't bind with that ACE2 receptor, to get more benefit out of this, one must therefore keep as many ACE2 receptors bound with quercetin, meaning continuous large dosages of quercetin, up till 4 x 250mg - 500mg per day, and then it still won't work as well as HCQ from preventing the coronavirus from entering the cell. The EVMS thinks 2 x 250 -500mg per day is sufficient, I guess it depends at what time you are exposed, make sure you just took quercetin before exposure, in that case, 250mg for 6 hours of some decent ACE2 saturation might do, having a higher amount of ACE2 receptors 'occupied' with quercetin shortly after taking it than at the end of those 6 hours. See previous comment as to how HCQ does this more permanently, with a longer-lasting effect that requires less continuous usage like with quercetin; this is what gives it some limited* prophylactic function as well. *: compared to HCQ. Other functions are anti-inflammatory in relation to the cytokine storm. And not entirely sure, but I think I also read something about antiviral effects (unless they were referring to what I just explained concerning the ACE2 receptor). It's also a zinc ionophore.
Zinc (inhibits viral replication after the cell has been infected, as long as you get it into the cell, does not prevent healthy cells from getting infected or have any antiviral effects outside of cells; zinc ionophore thus required, HCQ is the best zinc ionophore, the ratio of effectiveness as a zinc ionophore for HCQ, EGCG from green tea, and Quercetin is 7:4:2 if I remember correctly)
Copper (just to complement the uptake of zinc and prevent copper shortage if taking lots of zinc, 10:1 ratio with zinc)
Vitamin C (500mg twice a day in the EVMS prophylaxis protocol, 1000mg twice a day in Dr. Ban's protocol for Covid-19 patients with severe respiratory issues; functions as an anti-inflammatory and immunesystem-regulator)
Vitamin D3 (immuno-regulator, immuno-boosting effects)
Melatonin (very specific effects in relation to the cytokine storm, reducing the production of a particular protein or enzyme that is causing a lot of the trouble in the cytokine fire, come to think of it, I think that was cytokines themselves, or some component of a cytokine, or a particular type of cytokine)
The Eastern Virgina Medical School has all these supplements listed in their prophylaxis protocol, which I probably already linked in this thread (otherwise the link is in the thread about Trump and HCQ). It also lists Famotidine as optional (but that's not a supplement). Links to the relevant scientific articles explaining the function of these supplements in relation to Covid-19 (cause I haven't explained all those functions and effects, only the ones that interested me the most in evaluating which ones I should take for prophylaxis or just being ready for the fight) can be found in their pdf as well.
So to sum up the key ones for prophylaxis (or just getting ready for the fight, boost your immune system a bit, preparing it), based on not being able to get HCQ which is the only one that actually works well (these supplements don't quite do the trick, but are still better than nothing):
Quercetin
zinc (+ copper, like 20mg zinc + 2mg copper for example, 10:1 ratio ; I myself am taking 55mg + 1.5mg because of the way my supplements are comprised, it's not that crucial I think, my multi-vitamin is the only one with copper and has a 10:1 ratio, 15mg zinc + 1.5mg copper; my zinc tablets are not combined with copper; I'll just have to make do)
Vitamin C
Vitamin D3
And I would say optional: melatonin (the EVMS doesn't have this as an optional but part of their standard cocktail, see details in the supporting articles mentioned by them)
originally posted by: whereislogic
originally posted by: McGinty
a reply to: Serdgiam
...
However, I’m just as bad with the proliferation of supplements I’m now consuming to try and protect myself from the virus (around 11 different pills p/day) without any real knowledge regarding their dose, effects and relationships with each other. But I need to put up a fight of some kind - to be proactive rather than simply hope for the best.
You can probably cut that down a little, regarding supplements, these are the most important in relation to Covid-19:
Quercetin (especially if you can't get HCQ, otherwise it's less important; effects or functions: it binds with the ACE2 receptor, keeping it occupied so that the coronavirus can't bind with that ACE2 receptor, to get more benefit out of this, one must therefore keep as many ACE2 receptors bound with quercetin, meaning continuous large dosages of quercetin, up till 4 x 250mg - 500mg per day, and then it still won't work as well as HCQ from preventing the coronavirus from entering the cell. The EVMS thinks 2 x 250 -500mg per day is sufficient, I guess it depends at what time you are exposed, make sure you just took quercetin before exposure, in that case, 250mg for 6 hours of some decent ACE2 saturation might do, having a higher amount of ACE2 receptors 'occupied' with quercetin shortly after taking it than at the end of those 6 hours. See previous comment as to how HCQ does this more permanently, with a longer-lasting effect that requires less continuous usage like with quercetin; this is what gives it some limited* prophylactic function as well. *: compared to HCQ. Other functions are anti-inflammatory in relation to the cytokine storm. And not entirely sure, but I think I also read something about antiviral effects (unless they were referring to what I just explained concerning the ACE2 receptor). It's also a zinc ionophore.
Zinc (inhibits viral replication after the cell has been infected, as long as you get it into the cell, does not prevent healthy cells from getting infected or have any antiviral effects outside of cells; zinc ionophore thus required, HCQ is the best zinc ionophore, the ratio of effectiveness as a zinc ionophore for HCQ, EGCG from green tea, and Quercetin is 7:4:2 if I remember correctly)
Copper (just to complement the uptake of zinc and prevent copper shortage if taking lots of zinc, 10:1 ratio with zinc)
Vitamin C (500mg twice a day in the EVMS prophylaxis protocol, 1000mg twice a day in Dr. Ban's protocol for Covid-19 patients with severe respiratory issues; functions as an anti-inflammatory and immunesystem-regulator)
Vitamin D3 (immuno-regulator, immuno-boosting effects)
Melatonin (very specific effects in relation to the cytokine storm, reducing the production of a particular protein or enzyme that is causing a lot of the trouble in the cytokine fire, come to think of it, I think that was cytokines themselves, or some component of a cytokine, or a particular type of cytokine)
The Eastern Virgina Medical School has all these supplements listed in their prophylaxis protocol, which I probably already linked in this thread (otherwise the link is in the thread about Trump and HCQ). It also lists Famotidine as optional (but that's not a supplement). Links to the relevant scientific articles explaining the function of these supplements in relation to Covid-19 (cause I haven't explained all those functions and effects, only the ones that interested me the most in evaluating which ones I should take for prophylaxis or just being ready for the fight) can be found in their pdf as well.
So to sum up the key ones for prophylaxis (or just getting ready for the fight, boost your immune system a bit, preparing it), based on not being able to get HCQ which is the only one that actually works well (these supplements don't quite do the trick, but are still better than nothing):
Quercetin
zinc (+ copper, like 20mg zinc + 2mg copper for example, 10:1 ratio ; I myself am taking 55mg + 1.5mg because of the way my supplements are comprised, it's not that crucial I think, my multi-vitamin is the only one with copper and has a 10:1 ratio, 15mg zinc + 1.5mg copper; my zinc tablets are not combined with copper; I'll just have to make do)
Vitamin C
Vitamin D3
And I would say optional: melatonin (the EVMS doesn't have this as an optional but part of their standard cocktail, see details in the supporting articles mentioned by them)
originally posted by: ManFromEurope
NO at Hydroxycholorquine, and you can't get a better study:
The Lancet, full article, full peer-reviewed
14 888 patients were in the treatment groups (1868 received chloroquine, 3783 received chloroquine with a macrolide, 3016 received hydroxychloroquine, and 6221 received hydroxychloroquine with a macrolide) and 81 144 patients were in the control group.
We were unable to confirm a benefit of hydroxychloroquine or chloroquine, when used alone or with a macrolide, on in-hospital outcomes for COVID-19. Each of these drug regimens was associated with decreased in-hospital survival and an increased frequency of ventricular arrhythmias when used for treatment of COVID-19.
Now shut the f! up about HCQ as a wonderdrug and let us rheumatics take this really needed drug! I can't believe that I have to PREORDER and HAVE TO HOPE that it will be delievered, because some idiot told other idiots what to do!