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I'm not recommending anything, just passing this along from another post that seemed to have some understanding of how quinine (and chloroquine and hydroxychloroquine work).
...
Quinine acts against malaria by targeting its purine nucleoside phosphorylase enzyme (PfPNP) [3], but it has other effects in the body which act against coronavirus.
Namely, it targets angiotensin-converting enzyme 2 (ACE2) [4], interfering with sialic acid biosynthesis [4]. SARS, MERS and Covid-19 use sialic acid moieties as receptors, so quinine (and its synthetic counterparts) prevent viral attachment to cell receptors. [whereislogic: the main function for prophylaxis]
Hydroxychloroquine / Chloroquine / quinine can also act on the immune system through cell signalling and regulation of pro-inflammatory cytokines. [4]
...
[4] New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19? - ScienceDirect
originally posted by: whereislogic
What a surprise, another negative marketing/sales-pitch report. More to follow, as predicted.
All produced by scientists who were quiet about the blatant bias and scientific fraud concerning the VA study, providing evidence that none of their publications can be trusted in the future.
...
And as also predicted before, the newer reports will be much better at giving the appearance of being legit and having no conflict of interest compared to the VA study (which almost looks intentional, the VA study was so blatantly corrupt and deceitful, that any negative report about HCQ thereafter looks like a scientific gem of integrity in comparison, even though it's just more of the same, but dressed better), where almost halve the scientists on that study are known to have received funding from Gilead or otherwise have significant financial ties with Gilead (Remdesivir).
Here's the last time I responded to another one of these attempts to present these marketing/sales-pitch reports under the marketinglabel "Science":
originally posted by: whereislogic
a reply to: Grimpachi
...
The New England Journal of Medicine (your source of publication) has lost all credibility. Anyone who thinks they've got something worth your while to publish, check out the 2nd video of Dr. Raoult for a response to the NEJM and their behaviour in terms of scientific integrity and honesty vs a conflict of interest with Big Pharma pulling the strings.
From the piece you quoted yourself, as if you don't even get how such a negative marketing/sales-pitch report works:
Hydroxychloroquine-treated patients were more severely ill at baseline than those who did not receive hydroxychloroquine...
Basically the same trick as the VA study. ...
originally posted by: whereislogic
a reply to: Phage
Here's my prediction [edit: expectation] regarding the ongoing (mostly) government-funded clinical trials ...:
Each and every one will paint a negative picture on HCQ's already well-established and proven effectiveness both as a prohylaxis and treatment of Covid-19 (more so when optimized with ...).
... How can I know ahead of time that none will send out the message that HCQ has clear benefits (that outweigh any minimal risks concerning QT prolongation, i.e, ventricular arrhythmia*)? Even though frontline experience and honest statistics have already shown clear benefits in spite of all the denial that we already have sufficient data and don't need manipulated so-called "randomized clinical trials" that are really better described as marketing/sales-pitch reports once they are published (again by publishers who said nothing about the VA study akin to what Dr. Raoult had to say about it)? Why is NEJM still in business publishing so-called "scientific articles"? NEJM = The New England Journal of Medicine (who published something about Remdesivir, as discussed by Dr. Raoult in the video of my longer comment on the previous page, and was also the publisher of the article about HCQ that Grimpachi brought up in another thread, another favorite publication of the mainstream media, in particular on the left).
*: something easily fixed in those extremely rare cases where it does occur, by switching from Azithromycin to Doxycycline, showing that it's not HCQ that is the problem here; not to mention all the other drugs that are prescribed for minor issues that also can cause QT prolongation, psych drugs that often do more harm than good for actual unproven benefits. Used all the time with no one complaining about how dangerous they are.
We used a pragmatic approach to recruitment and follow-up of participants through Internet-based self-referral and online follow-up surveys, and we couriered the trial interventions directly to participants’ homes.
Full adherence to the trial intervention differed according to trial group, with 75.4% of participants in the hydroxychloroquine group (312 of 414)...all 19 prescribed tablets...
No arrhythmias or deaths occurred. ... Nausea, loose stools, and abdominal discomfort were the most common side effects. There were no serious intervention-related adverse reactions or cardiac arrhythmias.
Kevin McKernan
@Kevin_McKernan
·
8 u
The placebo (Folic Acid) has reported activity against SARS-CoV-2.
The lack of molecular testing means it could be underpowered.
80% of symptomatics in contact with CV test neg on qPCR. The majority of patients may have a diff virus.
...
The Role of Folic Acid in the Management of Respiratory Disease Caused by COVID-19
Novak
@Novak51327248
·
15 u
Als antwoord op
@EricTopol
@BallouxFrancois
en 5 anderen
HCQ will not prevent the body from developing antibodies or from catching the virus. But it may help fighting it. What is the point of this study? am I wrong about something?
Babak Javid
@Babak_Javid_Lab
·
16 u
Als antwoord op
@EricTopol
@lauriemcginley2
en 4 anderen
Gotta love the Press release before the data published trend in Covid-times!!
Hakim Dehbi
@HakDehbi
·
12 u
A concerning trend!
QAnon, MD, PhD
@RightDoctor
·
16 u
Als antwoord op
@EricTopol
@lauriemcginley2
en 4 anderen
"The study was conducted in an unusual way: over the internet, without patients being seen by study doctors"
Jaspreet S Photography
@JaspreetSPhoto
·
14 u
Indian study wasn't done on Internet but health care workers were taking it. they said it reduces viral load compared others who were not taking it.
JoshticeMed
@jgtm1234
·
14 u
Just skimming it I don't think it was possible to assess the question with the study design and sample size. Only 2 severe cases/hospitalizations in entire study (1 in each group)
Hakim Dehbi
@HakDehbi
·
12 u
Als antwoord op
@EricTopol
@BallouxFrancois
en 5 anderen
@EricTopol
absence of evidence isn't evidence of absence. When you say "... shows a lack of efficacy", you're falling into this trap. The CI is from - 2 to 7%. This is large and include potentially very large treatment effect (as well as harm), because of a small sample size.
PSK
@psk1510
·
7 u
Als antwoord op
@EricTopol
@sumanthraman
en 5 anderen
Some scientists and doctors must have spent more time in proving ineffectiveness (by hook or by crook) of hydroxychloroquine- then anything good about it. ...
originally posted by: andy06shake
a reply to: JBurns
Can we not just swap Hydroxychloroquine and bring back Methaqualone?
Problem solved, to some degree at least.
You can only take it for TWO(2) Weeks.
originally posted by: spacedoubt
He stopped taking his drugs.
So he says.
for now he decided to just say no to those drugs.
I think they were messing with his balance, high heels and shoe lifts are a challenge I suppose, under ordinary circumstances.
A large, randomized U.K. trial found “no clinical benefit” of hydroxychloroquine to treat hospitalized Covid-19 patients, researchers announced Friday.
“It doesn’t work,” declared Martin Landray, one of the lead researchers, at a briefing. Patients receiving hydroxychloroquine died at about the same rate — about one in four — as those receiving regular care in a randomized trial being conducted by the University of Oxford and the U.K. National Health Service.
originally posted by: Arnie123
You can only take it for TWO(2) Weeks.
originally posted by: spacedoubt
He stopped taking his drugs.
So he says.
for now he decided to just say no to those drugs.
I think they were messing with his balance, high heels and shoe lifts are a challenge I suppose, under ordinary circumstances.
Just do a bit of research and all your answers will be revealed.
originally posted by: Butterfinger
a reply to: Sookiechacha
Heat disease deaths by HCQ: 0