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The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, ...
...The spike is essential for both host specificity and viral infectivity.
....The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor.
....The S protein plays key parts in the induction of a neutralizing-antibody and T-cell responses, as well as protective immunity. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion;
.... Main component to bind with the neutralizing antibody; Key target for vaccine design; Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate.
originally posted by: MichiganSwampBuck
ETA: I just read your link (Corona Virus Updates Part 3). Holy Christ, maybe they did perfect it and it's ready to wipe us all out.
basically, after the body has successfully produced it's antibodies (attached to the immunoglobulin), the virus can come back in and attack the immune system directly by using the antibodies to mediate entry into the cells by modifying the immunoglobulin.... thus disabling the body's immunity to the virus and allowing the viral infection to penetrate more deeply the second time around.
originally posted by: tgidkp
originally posted by: MichiganSwampBuck
ETA: I just read your link (Corona Virus Updates Part 3). Holy Christ, maybe they did perfect it and it's ready to wipe us all out.
despite the recent back-patting here on ATS and elsewhere on the web....
... i honestly believe (based on the academic research i have read) that the second "wave" of reinfection is the real killer. we ought not to underestimate the virus' ability to disable the immune system.
again, this is a "gain of function", programmed into the virus, inside a laboratory.
basically, after the body has successfully produced it's antibodies (attached to the immunoglobulin), the virus can come back in and attack the immune system directly by using the antibodies to mediate entry into the cells by modifying the immunoglobulin.... thus disabling the body's immunity to the virus and allowing the viral infection to penetrate more deeply the second time around.
Molecular Mechanism for Antibody-Dependent Enhancement of Coronavirus Entry
originally posted by: rickymouse
So the article at the bottom of that post you made, does it imply that if they vaccinate we might have an increased risk of a secondary infection worse than an initial first infection?
originally posted by: tgidkp
a reply to: asabuvsobelow
i have, of course, been following the scandal of empty hospitals and the pent-up jobless angry mobs. and naturally, i am not in favor of what *seems to be* a poor response by our governments.
but i cannot help but feel tentative and uneasy about any definitive statements that the virus is a dud. so, i am torn. (but suffering one hell of a lot of anxiety).
i can't say what direction this is headed.... but from what i can tell, this is a dangerous virus and we absolutely have not yet seen the half of it.
make good decisions. keep yourself and your community healthy.
All those with the highest level of HIV immunity share a pair of mutated genes – one in each chromosome – that prevent their immune cells from developing a "receptor" that lets the AIDS virus break in. If the so-called CCR5 receptor – which scientists say is akin to a lock – isn't there, the virus can't break into the cell and take it over.
originally posted by: asabuvsobelow
My point is we cant live in fear of Covid-19 reinfections , Just connect the dots here and it's obvious we are looking at a new seasonal Virus, eventually we will have a vaccine of sorts and we will live with Covid-19 just like we live with the Flu, So in truth we should just get used to it because we cant afford to React the same way every time Covid-19 hits , that is not an option.
originally posted by: MotherMayEye
originally posted by: asabuvsobelow
My point is we cant live in fear of Covid-19 reinfections , Just connect the dots here and it's obvious we are looking at a new seasonal Virus, eventually we will have a vaccine of sorts and we will live with Covid-19 just like we live with the Flu, So in truth we should just get used to it because we cant afford to React the same way every time Covid-19 hits , that is not an option.
There is still this big mystery about 'reinfection.'
Some studies suggest there may be an 'antibody dependent enhancement' issue looming ahead, which means that a second wave may be much more severe.
Molecular Mechanism for Antibody-Dependent Enhancement of Coronavirus Entry
That study is from 2015.
If this virus was designed in a lab, and there is a grave risk with second infections due to antibody dependent enhancement -- then those who designed it know.
Next fall...right around election time there could be justified panic.
If this virus was designed in a lab, and there is a grave risk with second infections due to antibody dependent enhancement -- then those who designed it know.
originally posted by: asabuvsobelow
If that is true then the latter must also be true, meaning those who designed it know how the virus is going to react and they also know that they Designed a Vaccine or a way to control there " Designer Virus" .
originally posted by: MotherMayEye
originally posted by: asabuvsobelow
If that is true then the latter must also be true, meaning those who designed it know how the virus is going to react and they also know that they Designed a Vaccine or a way to control there " Designer Virus" .
Yes.
And, I suspect everything is fully under control...all is going according to plan. Nothing and no one is standing in the way.
originally posted by: MotherMayEye
Yes.
And, I suspect everything is fully under control...all is going according to plan. Nothing and no one is standing in the way.
At least 51 patients have tested positive for the second time in Daegu, days after they were discharged.
However, experts have ruled out a re-infection. They are pointing at two possibilities: First, the virus may have reactivated - it was dormant and then became active again.
Second, the tests were faulty and could not detect the virus.
It's clear that the threat of the coronavirus cannot be ruled out too easily. It remains hidden in humans, even after it appears to have been cured.