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Uncanny similarity of unique inserts in the 2019-nCoV spike protein to HIV-1 gp120 and Gag
Pradhan et al
We are currently witnessing a major epidemic caused by the 2019 novel coronavirus (2019- nCoV). The evolution of 2019-nCoV remains elusive. We found 4 insertions in the spike glycoprotein (S) which are unique to the 2019-nCoV and are not present in other coronaviruses. Importantly, amino acid residues in all the 4 inserts have identity or similarity to those in the HIV-1 gp120 or HIV-1 Gag. Interestingly, despite the inserts being discontinuous on the primary amino acid sequence, 3D-modelling of the 2019-nCoV suggests that they converge to constitute the receptor binding site. The finding of 4 unique inserts in the 2019-nCoV, all of which have identity /similarity to amino acid residues in key structural proteins of HIV-1 is unlikely to be fortuitous in nature. This work provides yet unknown insights on 2019-nCoV and sheds light on the evolution and pathogenicity of this virus with important implications for diagnosis of this virus.
originally posted by: TEOTWAWKIAIFF
HIV 1 gp120 is "out layer" to HIV itself (so says one paper) and I see "glycoprotein" which is a surface lipid of cell membranes. This is all about the immune response and how HIV enters the biological system.
All that being said, there is a bunch of research upon the subject which probably means there are labs working on it.
This all rather brings back that nagging suspicion over the BL-4 in Wuhan as a possible source. Yeah, it is probably fake news and internet gossip, but when a paper comes out and says that the likelihood of it being a random mutation seem not likely, well, then, like Sherlock Holmes says, we are left with fewer answers that make sense. I for one do not buy into the "snake in market" narrative at all.
Good find! Way to keep everyone on their toes about this! And our minds open to other possibilities rather than the official narrative.