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The results were really surprising, however scientists suggests that the findings are preliminary because the trial was small and did not include a control arm.
The study involved nine healthy volunteers, who were given a cocktail of three common drugs for a year- growth hormone and two diabetes medications. When scientists analysed marks on a person’s genomes, they found that the volunteers aged backwards- losing an average of 2.5 years from their biological ages.
The marks on their genomes represent their epigenetic clock, as well as their immune systems, actually improved despite the passing of time. Moreover, the volenteers’ immune systems also showed signs of rejuvenation.
A person's Epigenetic clock is estimated by the body’s epigenome – a record of chemical changes to an organism’s DNA. As people age, chemical adjustments or labels are added to people’s DNA, and those change for the duration of their lives, so by taking a gander at those tags an individual’s natural age can be estimated.
Through this study, scientists actually wanted to observe how the growth hormone would change the tissue in the thymus gland, which is is crucial for efficient immune function. Various studies have shown that growth hormone stimulates regeneration of the thymus. But, this harmone can also lead to diabetes. Thus, the study included two widely used anti-diabetic drugs,
Scientists looked at four different measures of the epigenetic clock to understand the differing ages of each of the patients. They found that each volunteer had reversed significantly.
“This told me that the biological effect of the treatment was robust. What’s more, the effect persisted in the six participants who provided a final blood sample six months after stopping the trial.”
“Because we could follow the changes within each individual, and because the effect was so very strong in each of them, I am optimistic.”
originally posted by: Oleandra88
I have a hard time understanding this.
As far as I know, every cell starts out with around 10 kilobases and each time it copies itself, a bit is cut at the end of the telomeres. Until one day, it can not copy anymore and we start to decay / die slowly.
Cancer cells do not go through this and this is why they can copy like infinite and become a problem. I would not volunteer before at least 10 years have passed and they looked at the testgroup again.
How many are still alive?
Is there a statistical uprise in cancer?
Is the effect still noticeable after 10 years? Has it reversed or nullified by 10 years?
Edit: Here is the source for the entry message: