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The study, published this week in the journal Proceedings of the National Academy of Sciences (PNAS), monitored 31 healthy white men aged 18 to 35.
When the researchers measured the testosterone/luteinizing hormone (LH) ratio in the participants, they found that the ibuprofen group experienced an 18 percent ratio decrease after 14 days. That number rose to a 23 percent decrease after 44 days. "Taken together, these in vivo data suggest that ibuprofen induced a state of compensated hypogonadism during the trial..." the study states.