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Another Research Paper Finds Aluminum Adjuvants in Vaccines do Cause Autism.

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posted on Sep, 27 2017 @ 10:02 PM
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a reply to: ElectricUniverse

Thanks for sharing... keep the information and chance of possible growing knowledge coming. This should be a debate that doesn't end, for the simple reasons that ASD is at epidemic rates.




www.cdc.gov...



www.cdc.gov...


Hmmm... a law that is claimed to be 'MERCURY-FREE' that states its allowable limits. C'mon... it's time to wake up and take our immune systems back.
edit on 27-9-2017 by ttobban because: replied to wrong person...

edit on 27-9-2017 by ttobban because: (no reason given)

edit on 27-9-2017 by ttobban because: (no reason given)




posted on Sep, 27 2017 @ 10:42 PM
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a reply to: ElectricUniverse

I thought the concern was mercury....



posted on Sep, 27 2017 @ 10:43 PM
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a reply to: Blue Shift

Ummmmm you would have been vaccinated... id get checked for early onset alzheimers,....



posted on Sep, 27 2017 @ 10:51 PM
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The way aluminum works is neuro-toxic. Alum in pickles is not good either, neither is baking powder containing aluminum. We still have alum in our cupboard, a little in something can hyperactivate someone's immune system if it does not work.

Injecting even a small amount into the body in a vaccine can trigger some immune system mistakes that can probably hurt young kids and also pregnant mothers. I have read a lot about how these adjuvants work and I have decided that aluminum adjuvants in vaccines is not good for a lot of people. I avoid alum as much as possible now and we now use aluminum free baking powder. Injesting alum in pickles isn't good if you eat a lot of pickles.

I spent a lot of time on that research and can't be convinced anymore that it is safe to consume or inject aluminum chemistry other than the small amounts in food naturally.



posted on Sep, 27 2017 @ 11:34 PM
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a reply to: Phage

Thats how science works Phage. I mean unless you arent into science and logic.



posted on Sep, 28 2017 @ 03:10 AM
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How can they may those claims on a mouse? it is not even a close analogue to the human brains neurobiology make up.

They're making those claims, and yet, we do not even know the actual causes and mechanisms on how Autism even comes about.

I'm not about to start listening to who is using a mouse brain doing a neurobiology research paper that is flawed from the start.f
edit on 28-9-2017 by MuonToGluon because: Fixed



posted on Sep, 28 2017 @ 07:17 AM
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a reply to: ElectricUniverse

I don't know whether they're on the right path, but I've suspected for a long time that autism, and it's increasing prevalence, is cause by a combination of factors.

Vaccine marketers point to the fact that not everyone who takes their vaccines gets autism. They're correct, in that vaccines alone clearly aren't the problem. Some combination of genetics and environment are certainly to blame.

The "environment" portion, I believe has to do with something (or things) that are relatively new to the environment. Whether that's vaccines for every minor possible disease we can come up with a vaccine for, and/or neurotoxic pesticides, there are others exposed to the same amount of environmental risk with no adverse effects. Thus: genetic component (and luck.)

At least there's signs more are looking towards multiple-factor implications.



posted on Sep, 28 2017 @ 09:38 AM
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I see we have the typical pro-VAX crowd arguments... IE, using logical fallacy when it suits them, and trying any possible way to cut around studies that they don't like...

This is why I don't argue about this anymore. It's useless.

Just because they develop the same chemical characteristics as a brain affected with a neurodegenerative disease, doesn't mean that they actually have it, because we can't talk to them?

You can't make this stuff up.



posted on Sep, 28 2017 @ 11:32 AM
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originally posted by: Aeshma
Ummmmm you would have been vaccinated... id get checked for early onset alzheimers,....

I don't remember being vaccinated. So I must have it!



posted on Sep, 28 2017 @ 11:50 AM
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a reply to: ElectricUniverse

No, the paper doesn't state what the title of your thread suggests.

But to the naysayers, you know very well that testing things on mice and inspecting the results and postulating similar things in humans has been a standard for a variety of things, to include carcinogens. We base many, many medical and scientific hypotheses based on the results from testing things on animals, so immediately disregard the tests and the resulting POSSIBLE correlation between aluminum and possible autism-causing physiological changes is not something to just jettison because, as Phage puts it, "You know that mice are not human, right?"

Gee, thanks for that bit of wisdom, Phage.

What this MAY be is another step in the long staircase that has never been fully climbed that leads to the cause of Autism. I for one will not condemn the study, but I also will not even remotely concede that they've found the trigger for Autism.

It's a good thread, but probably shouldn't contain such definitive statements, such as what the thread title says.

The video interview of that woman was a good one, though, so good inclusion of that.



posted on Sep, 28 2017 @ 11:52 AM
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originally posted by: Aeshma
a reply to: ElectricUniverse

I thought the concern was mercury....


The concern is the myriad of things in that cocktail of an elixir that we call vaccines, coupled with the age at which they claim that they are necessary and the quantity that they advise giving them to your child.



posted on Sep, 28 2017 @ 11:53 AM
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No where did it say aluminum causes autism. It causes inflammation in brain tissues, thought to be associated with autism. Mind you, this study was done on mice, who by the way aren't humans in case you were confused by that.




posted on Sep, 28 2017 @ 12:19 PM
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a reply to: PorteurDeMort

So by your logic, that means that every single study ever done on an animal, has to be completely disregarded and thrown out? That's a mighty tall assumption. I mean, this link below shows some of the main reasons that mice are used in tests, one of the reasons being that mice quoted as:




Another reason rodents are used as models in medical testing is that their genetic, biological and behavior characteristics closely resemble those of humans, and many symptoms of human conditions can be replicated in mice and rats. "Rats and mice are mammals that share many processes with humans and are appropriate for use to answer many research questions," said Jenny Haliski, a representative for the National Institutes of Health (NIH) Office of Laboratory Animal Welfare.


Saying that they aren't human as a means to disqualify a certain study simply because it goes against a cognitive bias is.... well..... logically flawed and biased.


www.livescience.com...



posted on Sep, 28 2017 @ 03:06 PM
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a reply to: Phage

Hello page .. have your kids been vacanated ? If you have kids ? I'm on the fence with the information out there .. I didn't want my baby having them but her mother wanted them .. so she had them 😔 She seems fine so I can't say much really .



posted on Sep, 29 2017 @ 05:53 PM
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originally posted by: Phage

This experiment was not a test of a new medicine. Those protocols are quite different

Which animals are suitable analogs for human neurobiology? And what reason is there to believe that, even if there were inflammation of mouse brains, it has anything to do with autism?

Another paper by the same crew. Oops.
www.skepticalraptor.com...


BTW, Phage, in case you didn't know studies done on primates, monkeys, also show that aluminum adjuvants, and other additives used in vaccines such as thimerosal do cause neurological problems. Such studies have been posted before in these forums.

As for your question of what does brain inflammation have to do with autism?...

Here is a non-blogger research paper about the link, there are many others Phage...


Front Cell Neurosci. 2015; 9: 519.
Published online 2016 Jan 19. doi: 10.3389/fncel.2015.00519
PMCID: PMC4717322
Relevance of Neuroinflammation and Encephalitis in Autism
Janet K. Kern,1,* David A. Geier,1 Lisa K. Sykes,2 and Mark R. Geier1
1Institute of Chronic Illnesses, Inc., Silver Spring, MD, USA
2CoMeD, Inc., Silver Spring, MD, USA
Edited by: Antonio Gambardella, Magna Græcia University, Italy
Reviewed by: Adelaide Fernandes, University of Lisbon, Portugal; Tatsuro Mutoh, Fujita Health University School of Medicine, Japan
*Correspondence: Janet K. Kern,

Abstract

In recent years, many studies indicate that children with an autism spectrum disorder (ASD) diagnosis have brain pathology suggestive of ongoing neuroinflammation or encephalitis in different regions of their brains. Evidence of neuroinflammation or encephalitis in ASD includes: microglial and astrocytic activation, a unique and elevated proinflammatory profile of cytokines, and aberrant expression of nuclear factor kappa-light-chain-enhancer of activated B cells. A conservative estimate based on the research suggests that at least 69% of individuals with an ASD diagnosis have microglial activation or neuroinflammation. Encephalitis, which is defined as inflammation of the brain, is medical diagnosis code G04.90 in the International Classification of Disease, 10th revision; however, children with an ASD diagnosis are not generally assessed for a possible medical diagnosis of encephalitis. This is unfortunate because if a child with ASD has neuroinflammation, then treating the underlying brain inflammation could lead to improved outcomes. The purpose of this review of the literature is to examine the evidence of neuroinflammation/encephalitis in those with an ASD diagnosis and to address how a medical diagnosis of encephalitis, when appropriate, could benefit these children by driving more immediate and targeted treatments.
Keywords: neuroinflammation, encephalitis, autism spectrum disorder, microglia, astrocytic activation, cytokines, regression
...

www.ncbi.nlm.nih.gov...


edit on 29-9-2017 by ElectricUniverse because: correct comment.



posted on Sep, 30 2017 @ 11:25 AM
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originally posted by: ElectricUniverse

originally posted by: Phage

This experiment was not a test of a new medicine. Those protocols are quite different

Which animals are suitable analogs for human neurobiology? And what reason is there to believe that, even if there were inflammation of mouse brains, it has anything to do with autism?

Another paper by the same crew. Oops.
www.skepticalraptor.com...


BTW, Phage, in case you didn't know studies done on primates, monkeys, also show that aluminum adjuvants, and other additives used in vaccines such as thimerosal do cause neurological problems. Such studies have been posted before in these forums.

As for your question of what does brain inflammation have to do with autism?...

Here is a non-blogger research paper about the link, there are many others Phage...


Front Cell Neurosci. 2015; 9: 519.
Published online 2016 Jan 19. doi: 10.3389/fncel.2015.00519
PMCID: PMC4717322
Relevance of Neuroinflammation and Encephalitis in Autism
Janet K. Kern,1,* David A. Geier,1 Lisa K. Sykes,2 and Mark R. Geier1
1Institute of Chronic Illnesses, Inc., Silver Spring, MD, USA
2CoMeD, Inc., Silver Spring, MD, USA
Edited by: Antonio Gambardella, Magna Græcia University, Italy
Reviewed by: Adelaide Fernandes, University of Lisbon, Portugal; Tatsuro Mutoh, Fujita Health University School of Medicine, Japan
*Correspondence: Janet K. Kern,

Abstract

In recent years, many studies indicate that children with an autism spectrum disorder (ASD) diagnosis have brain pathology suggestive of ongoing neuroinflammation or encephalitis in different regions of their brains. Evidence of neuroinflammation or encephalitis in ASD includes: microglial and astrocytic activation, a unique and elevated proinflammatory profile of cytokines, and aberrant expression of nuclear factor kappa-light-chain-enhancer of activated B cells. A conservative estimate based on the research suggests that at least 69% of individuals with an ASD diagnosis have microglial activation or neuroinflammation. Encephalitis, which is defined as inflammation of the brain, is medical diagnosis code G04.90 in the International Classification of Disease, 10th revision; however, children with an ASD diagnosis are not generally assessed for a possible medical diagnosis of encephalitis. This is unfortunate because if a child with ASD has neuroinflammation, then treating the underlying brain inflammation could lead to improved outcomes. The purpose of this review of the literature is to examine the evidence of neuroinflammation/encephalitis in those with an ASD diagnosis and to address how a medical diagnosis of encephalitis, when appropriate, could benefit these children by driving more immediate and targeted treatments.
Keywords: neuroinflammation, encephalitis, autism spectrum disorder, microglia, astrocytic activation, cytokines, regression
...

www.ncbi.nlm.nih.gov...



You do realise that the "research paper" you've linked to isn't a research paper?
It's a literature review.
By a professional witness who specialises in vaccine litigation cases.

But you know that don't you?



posted on Sep, 30 2017 @ 12:48 PM
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abcnews.go.com...


It's not always the activity on the molecular level that can be a problem for a vaccinated population. Make vaccines an option, and the real debate comes forth... the internal human body and its natural defenses are not owned by our governing bodies.

It's one thing entirely to cave in on what a governing body advises is best for our children/immune systems, but how can those fear tactics be so impactful that the masses must move to mandate laws against those that don't want a governing body... to decide on their own child's involvement and or disinvolvement?

Seriously, it comes across as if people want other children vaccinated, for the simple reason that their children already played victim to the system. If that is the case, it's a bad principle to move on in this debate, because vaccinated people shouldn't theoretically get an ailment from one who is not vaccinated.

See how playing a role in support of what a governing body decides for masses and how it can and does endorse a snowball affect for propaganda rhetoric to move forward? Governing body's easily see that the masses are falling victim to the propaganda acts of the past, so there's no need to stop there... they already pulled enough vaccine support and are generations deep in synthetically altering our immune systems.

Now, we need vaccines where decades back it may have just been something to use as an aid. People think we aren't passing the genes of our synthetically altered immune systems onto our future generations for some reason, and it makes zero sense. Why do we think so many people are obese these days??? It's not so much that each individual has poor/faulty health standards... it's more likely that an obese person's ancestors did not consume carbohydrates to the degree that a skinny person's ancestors have... hence, we have situations where generations after the fact, sugar being consumed by our future generations will have a DIRECT correlation to what was consumed in past generations. Go figure... we really are what we eat.

So, take that sugar premise and apply it to vaccines. It shouldn't take a damn research paper and proof to sink in that people are what they eat. If you want to eat chemicals to keep an invisible fear from causing any harm, just understand that future generations of your DNA will likely not have as strong of a natural immune system as it could have previously. Let these poor choices stretch on for a few generations, and you have what we see now... herd immunity being told to us that it's effective, but it completely ignores its likely attachments to RNA coding/DNA structuring in future generations.

So, who do we really wish to have more control of the genetic make up of our future generations? Do we wish for economic policy makers to decide that humans must be mandated to pass on a synthetic platform to offspring? Honestly, it should be each of our own choice as parents, to move forward with the choice we wish for.

Stop with mandated vaccines already... a few brave parents that choose mother nature over government in these regards should not be put to fire for their choices. It's takes a brave soul to stand on their own in such regards, and they don't deserve to be reprimanded for their choices of free will. Not only is mandated vaccines immoral, the fear peddling should be put to a halt once a parent vaccines their child and or children. What's the point of getting vaccined initially if the fears of what was protected against are still lingering???



posted on Sep, 30 2017 @ 07:45 PM
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originally posted by: Aeshma
a reply to: ElectricUniverse

I thought the concern was mercury....


Thimerosal is one of the additives used which are of concern, but it isn't the only one. Aluminum in vaccines is another great concern. Aluminum is not needed by the human body, it is abundant but several studies have linked aluminum to Alzheimer's disease, among other neurodegenerative problems.



Masahiro Kawahara1,* and Midori Kato-Negishi2
1Department of Analytical Chemistry, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, 1714-1 Yoshino-cho, Nobeoka-shi, Miyazaki 882-8508, Japan
2Institute of Industrial Science (IIS), The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan
*Masahiro Kawahara: pj.ca.xineohp@asamawak
Academic Editor: Paolo Zatta

Abstract

Whilst being environmentally abundant, aluminum is not essential for life. On the contrary, aluminum is a widely recognized neurotoxin that inhibits more than 200 biologically important functions and causes various adverse effects in plants, animals, and humans. The relationship between aluminum exposure and neurodegenerative diseases, including dialysis encephalopathy, amyotrophic lateral sclerosis and Parkinsonism dementia in the Kii Peninsula and Guam, and Alzheimer's disease (AD) has been suggested. In particular, the link between aluminum and Alzheimer's disease has been the subject of scientific debate for several decades. However, the complex characteristics of aluminum bioavailability make it difficult to evaluate its toxicity and therefore, the relationship remains to be established. Mounting evidence has suggested that significance of oligomerization of β-amyloid protein and neurotoxicity in the molecular mechanism of AD pathogenesis. Aluminum may play crucial roles as a cross-linker in β-amyloid oligomerization. Here, we review the detailed characteristics of aluminum neurotoxicity based on our own studies and the recent literatures. Our aim is to revisit the link between aluminum and AD and to integrate aluminum and amyloid cascade hypotheses in the context of β-amyloid oligomerization and the interactions with other metals.
...

Link between Aluminum and the Pathogenesis of Alzheimer's Disease: The Integration of the Aluminum and Amyloid Cascade Hypotheses

Aluminum and Alzheimer's disease: after a century of controversy, is there a plausible link?


edit on 30-9-2017 by ElectricUniverse because: correct comment.



posted on Sep, 30 2017 @ 08:42 PM
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a reply to: MuonToGluon

So, you are telling us that you know more than scientists who have participated in the hundreds of research in which rats, and other animals were used to find any adverse effects that certain substances can have on humans?...

BTW, do any of you geniuses know why vaccines have animal derived materials if according to your "expert opinion" there is "not even a close analogue between human and animal make up"?...

It's not as if there are animal diseases that can be transferred to humans and would even affect the human brain right?...riiight?...

I mean rabies is just a "made up illness that affects humans as well as animal brains", right?... Some geniuses in these forums seem to think that they will be completely immune if an animal with rabies bites them. After all, the human brain and animal brains are not even close to being similar so rabies cannot be passed onto humans and affect us or so would some members claim...

Or how about...


Emergent human pathogen simian virus 40 and its role in cancer.
Vilchez RA1, Butel JS.
Author information

1
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Mail Stop BCM-385, One Baylor Plaza, Houston, TX 77030, USA.

Abstract

The polyomavirus simian virus 40 (SV40) is a known oncogenic DNA virus which induces primary brain and bone cancers, malignant mesothelioma, and lymphomas in laboratory animals. Persuasive evidence now indicates that SV40 is causing infections in humans today and represents an emerging pathogen. A meta-analysis of molecular, pathological, and clinical data from 1,793 cancer patients indicates that there is a significant excess risk of SV40 associated with human primary brain cancers, primary bone cancers, malignant mesothelioma, and non-Hodgkin's lymphoma. Experimental data strongly suggest that SV40 may be functionally important in the development of some of those human malignancies. Therefore, the major types of tumors induced by SV40 in laboratory animals are the same as those human malignancies found to contain SV40 markers. The Institute of Medicine recently concluded that "the biological evidence is of moderate strength that SV40 exposure could lead to cancer in humans under natural conditions." This review analyzes the accumulating data that indicate that SV40 is a pathogen which has a possible etiologic role in human malignancies. Future research directions are considered.
...

Emergent human pathogen simian virus 40 and its role in cancer.


Heck, here is a recent article from Yale on whether or not 'vaccines are safe"...


Vaccines linked to mental disorders by Yale study

Kevin Wang Feb 21, 2017

Staff Reporter

A recent Yale study has called into question the safety of vaccines and could lend fuel to anti-vaccine advocates like Robert F. Kennedy Jr., who has already written a piece covering the study on the news site EcoWatch.

The study, published last month in the journal Frontiers in Psychiatry, reports that patients diagnosed with neuropsychiatric disorders like obsessive-compulsive disorder and anorexia nervosa were more likely to have received vaccinations three months prior to their diagnoses. Though the collaboration between researchers at Pennsylvania State University and the Yale Child Study Center yielded results that seem to dispute the safety of vaccines, the authors asserted that the study needs replication on a larger scale and does not establish a causal relationship between vaccines and neuropsychiatric disorders.
...

yaledailynews.com...

Anyway...there are plenty of studies done on primates, and even on children and adults which show the same results...

Take your pick.



Abstract

Aluminum oxyhydroxide (alum) is a crystalline compound widely used as an immunological adjuvant of vaccines. Concerns linked to the use of alum particles emerged following recognition of their causative role in the so-called macrophagic myofasciitis (MMF) lesion detected in patients with myalgic encephalomyelitis/chronic fatigue/syndrome. MMF revealed an unexpectedly long-lasting biopersistence of alum within immune cells in presumably susceptible individuals, stressing the previous fundamental misconception of its biodisposition. We previously showed that poorly biodegradable aluminum-coated particles injected into muscle are promptly phagocytosed in muscle and the draining lymph nodes, and can disseminate within phagocytic cells throughout the body and slowly accumulate in brain. This strongly suggests that long-term adjuvant biopersistence within phagocytic cells is a prerequisite for slow brain translocation and delayed neurotoxicity. The understanding of basic mechanisms of particle biopersistence and brain translocation represents a major health challenge, since it could help to define susceptibility factors to develop chronic neurotoxic damage. Biopersistence of alum may be linked to its lysosome-destabilizing effect, which is likely due to direct crystal-induced rupture of phagolysosomal membranes. Macrophages that continuously perceive foreign particles in their cytosol will likely reiterate, with variable interindividual efficiency, a dedicated form of autophagy (xenophagy) until they dispose of alien materials. Successful compartmentalization of particles within double membrane autophagosomes and subsequent fusion with repaired and re-acidified lysosomes will expose alum to lysosomal acidic pH, the sole factor that can solubilize alum particles. Brain translocation of alum particles is linked to a Trojan horse mechanism previously described for infectious particles (HIV, HCV), that obeys to CCL2, signaling the major inflammatory monocyte chemoattractant.
...


Biopersistence and Brain Translocation of Aluminum Adjuvants of Vaccines

Mechanisms of aluminum adjuvant toxicity and autoimmunity in pediatric populations

Unequivocal identification of intracellular aluminium adjuvant in a monocytic THP-1 cell line

Are there negative CNS impacts of aluminum adjuvants used in vaccines and immunotherapy?



edit on 30-9-2017 by ElectricUniverse because: add and correct comment.



posted on Oct, 2 2017 @ 02:41 AM
link   

originally posted by: ElectricUniverse
a reply to: MuonToGluon

So, you are telling us that you know more than scientists who have participated in the hundreds of research in which rats, and other animals were used to find any adverse effects that certain substances can have on humans?...

BTW, do any of you geniuses know why vaccines have animal derived materials if according to your "expert opinion" there is "not even a close analogue between human and animal make up"?...

It's not as if there are animal diseases that can be transferred to humans and would even affect the human brain right?...riiight?...

I mean rabies is just a "made up illness that affects humans as well as animal brains", right?... Some geniuses in these forums seem to think that they will be completely immune if an animal with rabies bites them. After all, the human brain and animal brains are not even close to being similar so rabies cannot be passed onto humans and affect us or so would some members claim...

Or how about...


Emergent human pathogen simian virus 40 and its role in cancer.
Vilchez RA1, Butel JS.
Author information

1
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Mail Stop BCM-385, One Baylor Plaza, Houston, TX 77030, USA.

Abstract

The polyomavirus simian virus 40 (SV40) is a known oncogenic DNA virus which induces primary brain and bone cancers, malignant mesothelioma, and lymphomas in laboratory animals. Persuasive evidence now indicates that SV40 is causing infections in humans today and represents an emerging pathogen. A meta-analysis of molecular, pathological, and clinical data from 1,793 cancer patients indicates that there is a significant excess risk of SV40 associated with human primary brain cancers, primary bone cancers, malignant mesothelioma, and non-Hodgkin's lymphoma. Experimental data strongly suggest that SV40 may be functionally important in the development of some of those human malignancies. Therefore, the major types of tumors induced by SV40 in laboratory animals are the same as those human malignancies found to contain SV40 markers. The Institute of Medicine recently concluded that "the biological evidence is of moderate strength that SV40 exposure could lead to cancer in humans under natural conditions." This review analyzes the accumulating data that indicate that SV40 is a pathogen which has a possible etiologic role in human malignancies. Future research directions are considered.
...

Emergent human pathogen simian virus 40 and its role in cancer.


Heck, here is a recent article from Yale on whether or not 'vaccines are safe"...


Vaccines linked to mental disorders by Yale study

Kevin Wang Feb 21, 2017

Staff Reporter

A recent Yale study has called into question the safety of vaccines and could lend fuel to anti-vaccine advocates like Robert F. Kennedy Jr., who has already written a piece covering the study on the news site EcoWatch.

The study, published last month in the journal Frontiers in Psychiatry, reports that patients diagnosed with neuropsychiatric disorders like obsessive-compulsive disorder and anorexia nervosa were more likely to have received vaccinations three months prior to their diagnoses. Though the collaboration between researchers at Pennsylvania State University and the Yale Child Study Center yielded results that seem to dispute the safety of vaccines, the authors asserted that the study needs replication on a larger scale and does not establish a causal relationship between vaccines and neuropsychiatric disorders.
...

yaledailynews.com...

Anyway...there are plenty of studies done on primates, and even on children and adults which show the same results...

Take your pick.



Abstract

Aluminum oxyhydroxide (alum) is a crystalline compound widely used as an immunological adjuvant of vaccines. Concerns linked to the use of alum particles emerged following recognition of their causative role in the so-called macrophagic myofasciitis (MMF) lesion detected in patients with myalgic encephalomyelitis/chronic fatigue/syndrome. MMF revealed an unexpectedly long-lasting biopersistence of alum within immune cells in presumably susceptible individuals, stressing the previous fundamental misconception of its biodisposition. We previously showed that poorly biodegradable aluminum-coated particles injected into muscle are promptly phagocytosed in muscle and the draining lymph nodes, and can disseminate within phagocytic cells throughout the body and slowly accumulate in brain. This strongly suggests that long-term adjuvant biopersistence within phagocytic cells is a prerequisite for slow brain translocation and delayed neurotoxicity. The understanding of basic mechanisms of particle biopersistence and brain translocation represents a major health challenge, since it could help to define susceptibility factors to develop chronic neurotoxic damage. Biopersistence of alum may be linked to its lysosome-destabilizing effect, which is likely due to direct crystal-induced rupture of phagolysosomal membranes. Macrophages that continuously perceive foreign particles in their cytosol will likely reiterate, with variable interindividual efficiency, a dedicated form of autophagy (xenophagy) until they dispose of alien materials. Successful compartmentalization of particles within double membrane autophagosomes and subsequent fusion with repaired and re-acidified lysosomes will expose alum to lysosomal acidic pH, the sole factor that can solubilize alum particles. Brain translocation of alum particles is linked to a Trojan horse mechanism previously described for infectious particles (HIV, HCV), that obeys to CCL2, signaling the major inflammatory monocyte chemoattractant.
...


Biopersistence and Brain Translocation of Aluminum Adjuvants of Vaccines

Mechanisms of aluminum adjuvant toxicity and autoimmunity in pediatric populations

Unequivocal identification of intracellular aluminium adjuvant in a monocytic THP-1 cell line

Are there negative CNS impacts of aluminum adjuvants used in vaccines and immunotherapy?




Let's go through your studies...

1st one "This review analyzes the accumulating data that indicate that SV40 is a pathogen which has a possible etiologic role in human malignancies. Future research directions are considered."
No conclusion.

2nd one, reading past the headlines, deeper in the text it states this "Other findings in the study, however, reveal that these correlational results should be taken with a grain of salt."

3rd one, this isn't a reasearch article, it's essentially an opinion piece which references a fabricated illness, ASIA syndrome. Basically it's a work of fiction.

4th one, again references the fabricated illness ASIA syndrome. File in the fiction section.

5th one, can you tell me the relevance of this study to harm caused by aluminium as it doesn't state anything.

6th one, this is an abstract which contains no research whatsoever

FAIL.



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