I was recently involved in a thread on ATS regarding mandatory vaccines, the unfounded and often narrow minded responses have driven me to do
something I rarely do and that is make a thread.
For all the anti vaxxers out there, this is not an anti vax thread neither is it a pro vax thread. This is a conversation, a discussion about what
might be going wrong with our children. Our children are more important than your beliefs and I would ask you all to put those beliefs aside and read
the information I will try to present.
Before I get started you should know my background is in Genetics and Genetic engineering and I have had a number of years involved in vaccine
development albeit DNA vaccines (something we don't inject into children). I was a research scientist for the Australian government for 10-12
I started reading the literature on Autism after a friends child suffered what can only be described as a sudden and "unexplained' journey into severe
autism sixteen hours after a routine dTap vaccination. I didn't think for a minute the vaccine was the cause but I did think that the immune response
the vaccine generated may have triggered the event, and so perhaps there was a way to reverse it.
It appears that there is a strong genetic link to autism, but how did this suddenly occur? We are in an autism epidemic that has sprung up out of
nowhere and genetics doesn't work like that. If you find genetic markers for a disease it really only tells you that you have a predisposition for
that disease and often (not always) environmental factors can trigger it (I am keeping this as simple as I can). So logic dictates something
environmental must have changed in the last 10-15 years to trigger susceptible genotypes.
So I went looking for the physiological traits that are seen in the majority of Autism cases, low and behold we find that they share a couple of
common traits. Firstly we see a hyperactive immune response in the brain, cells called microglial cell exhibit an almost perpetual state of activity.
These cells should only activate when a pathogen or foreign substance is detected. They are responsible for inflammation, and indeed inflammation is
thought to be a leading cause of autism.
Now these cells are part of the innate immune system which directly effects the adaptive arm of our immune system. Vaccine adjuvants often target this
innate arm of the immune response. Adjuvants are the cocktail of chemicals and other things we use to invoke a strong immune response to the antigens
found in vaccines.
So lets take a moment shall we.... Don't let your emotions cloud your judgement.
So we have an immune disorder in the brain of young children which causes autism, we have children being exposed to immune stimulating adjuvants and
yet nobody can see a link, why is that? Well because unvaccinated children get autism too, unfortunately the science behind these studies is quite
poor and lacking in detail. So why would this be the case and why would cases of autism be exploding now when we have been vaccinating for
I then stumbled across an article about glyphosate and the effects it has on the gut flora of mice, it appears to have a highly disruptive effect on
the gut microbiota. This in turn effects the blood brain barrier permeability, allowing unwanted molecules to cross. The research suggests this gut
imbalance is passed from mother to child. Is the anecdotal evidence of vaccines causing autism actually a combination of a defective blood brain
barrier and over stimulation of the innate pathway? Is this why some cases of autism are linked to viral infections and the immune response
I could go on for pages but I will leave it there with a number of links if you care to read the science and draw your own conclusions.
Please be aware, vaccines have saved millions of lives and our world would be a very different place without them, and conversely please consider
those who choose not to vaccinate may be justified in some way. If you can all understand its about the children and the coming generations, not our
ego's and blind beliefs. For those of you who tell me there is no evidence, just remember science starts with theory....
Here we report results from a large-scale RNA sequencing effort, utilizing region-matched autism and control brains to identify neuronal and
microglial genes robustly dysregulated in autism cortical brain. Remarkably, we note that a gene expression module corresponding to M2-activation
states in microglia is negatively correlated with a differentially expressed neuronal module, implicating dysregulated microglial responses in concert
with altered neuronal activity-dependent genes in autism brains.
TextIn recent years, many studies indicate that children with an autism spectrum disorder (ASD) diagnosis have brain pathology suggestive of
ongoing neuroinflammation or encephalitis in different regions of their brains. Evidence of neuroinflammation or encephalitis in ASD includes:
microglial and astrocytic activation, a unique and elevated proinflammatory profile of cytokines, and aberrant expression of nuclear factor
kappa-light-chain-enhancer of activated B cells.
TextThere are many different ways of getting autism, but we found that they all have the same downstream effect," says Prof. Dan Arking regarding
his research team's finding that brains affected by autism share a pattern of inflammation as a result of increased immune responses.
Pivotal to brain development and function is an intact blood-brain barrier (BBB), which acts as a gatekeeper to control the passage and exchange of
molecules and nutrients between the circulatory system and the brain parenchyma. The BBB also ensures homeostasis of the central nervous system (CNS).
We report that germ-free mice, beginning with intrauterine life, displayed increased BBB permeability compared to pathogen-free mice with a normal gut
flora. The increased BBB permeability was maintained in germ-free mice after birth and during adulthood and was associated with reduced expression of
the tight junction proteins occludin and claudin-5, which are known to regulate barrier function in endothelial tissues. Exposure of germ-free adult
mice to a pathogen-free gut microbiota decreased BBB permeability and up-regulated the expression of tight junction proteins. Our results suggest that
gut microbiota–BBB communication is initiated during gestation and propagated throughout life.
edit on 25-6-2017 by Charlyboy because: (no