A new study confirms that prions, the infectious proteins that cause Mad Cow disease are found throughout the body. Organs previously thought to be
free of prions are now known to contain them, as well as muscle, skin and blood vessels. Yale and University of Zurich researchers report that
super-imposed infections play a role in causing prions to spread through the body. This study and other current research appears to validate
scientists previous claims that "subclinical" prion infections are common, and may underlie epidemic rising rates of heart disease, obesity, diabetes,
high blood pressure and various chronic disabilities.
www.medicalnewstoday.com
Prions, infectious proteins associated with bovine spongiform encephalopathy (BSE) or Mad Cow Disease, were previously thought to accumulate mainly
in the brain, but Yale and University of Zurich researchers report in Science that other organs can also become infected.
Past research had shown that the brain and spinal cord bear the highest infection risk for BSE, followed by organs such as the spleen, lymph nodes and
tonsils. All other organs were thought to be devoid of prions.
Ruddle and co-authors analyzed three organ systems that are typically free of prions: liver, pancreas and kidney, in five different mouse models of
chronic inflammation. After the mice were infected with prions, the team detected prion accumulation in the inflamed organs. They concluded that the
spectrum of organs containing prions might be considerably increased in situations of chronic inflammation.
"The study suggests that the current prion risk-classification of farm animal organs may need to be reassessed in animals suffering from inflammation
due to microbial infection or autoimmune disease,"...
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Earlier research by Adriano Aguzzi's team at the Institute of Neuropathology at University of Zurich showed that
prions use the immune system to spread through the body. This new study from Yale and
Zurich Universities supports Aguzzi's work, and takes it a step closer to practical applications.
There are wide-ranging implications for human health, which should be considered in a range of areas: from enforcement policies for Environmental
Protection Agency (EPA) regulations and water safety, through to planned modifications of the Social Security system.
Equally important, ordinary people need to be fully informed, and prepared to deal with the possible long-term consequences of subclinical prion
infections - high medical bills, early physical or mental disabilities and often, bankruptcy.
Medical bills spark 46% of U.S. personal bankruptcies
Background Information About Prions
Prion Information Primer
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