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A car has reportedly mounted the pavement on London Bridge before a stabbing attack, according to witnesses.
There are reports that a white van veered off the road on London bridge, hitting five or six people.
Police have confirmed they are dealing with an incident and armed police are at the scene.
London Transport Police say London Bridge station is also closed.
Will Heaven was at the scene shortly afterwards and wrote on Twitter that he had seen casualties - one on the pavement and one on the edge of the road.