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Constanzo began to believe that his magic spells, many of which he took from Palo Mayombe, were responsible for the success of the cartels and demanded to become a full business partner with one of the most powerful families he knew, the Calzadas. When his demand was rejected, seven family members disappeared. Their bodies turned up later with fingers, toes, ears, brains and even (in one case) the spine missing. Constanzo soon made friends with a new cartel, the Hernandez brothers. He also took up with a young woman named Sara Aldrete, who became the high priestess of the cult.
In 1988, Constanzo moved to Rancho Santa Elena, a house in the desert. It is there that he carried out more sadistic ritual murders, sometimes of strangers and other times of rival drug dealers. He also used the ranch to store huge shipments of coc aine and marijuana.
On March 13, 1989, Constanzo's henchmen abducted a pre-med student, Mark Kilroy, from outside a Mexican bar and took him back to the ranch. Kilroy was a U.S. citizen who had been in Mexico on spring break. When Kilroy was brought to the ranch, Constanzo murdered him. Under pressure from Texan politicians, Mexican police initially picked up four of Constanzo's followers, including two of the Hernandez brothers. Police quickly discovered the cult and that Constanzo had been responsible for Kilroy's death; he sought a "good"/superior brain for one of his ritual spells. Officers raided the ranch and discovered Constanzo's cauldron, which contained various items such as a dead black cat and a human brain.