posted on Oct, 17 2016 @ 02:12 PM
A nonsteroid anti-inflammatory (NSAID) drug used for treating colds has been found to suppress bladder cancer. Hokkaido University researchers found
that Flufenamic Acid, blocks a cancer’s enzyme.
They found high levels of AKR1C1(metabolic enzyme aldo-keto reductase 1C1) in metastatic tumors removed from 25 cancer patients. An inflammatory
substance produced around the tumor, such as interleukin-1β, increased the enzyme levels. AKR1C1 enhances tumor-promoting activities and proved that
the enzyme blocks the effectiveness of cisplatin and other anticancer drugs. The researchers finally discovered that inoculating flufenamic acid, an
inhibitory factor for AKR1C1, into cancerous bladder cells suppressed the cells' invasive activities and restored the effectiveness of anticancer
drugs. Flufenamic acid is also known as a nonsteroid anti-inflammatory drug used for treating common colds. It is an anthranilic acid derivative with
analgesic, anti-inflammatory, and antipyretic properties. It is used in musculoskeletal and joint disorders and administered by mouth and topically.
Dr. Shinya Tanaka of Hokkaido University states,” This latest research could pave the way for medical institutions to use flufenamic acid—a much
cheaper cold drug—which has unexpectedly been proven to be effective at fighting cancers.”
Also found at the University of North Carolina, Breast Cancer shares a low levels of the tight junction protein claudin. The UNC researchers now
document that claudin-low tumors represent a specific subtype of bladder cancer as well.
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edit on V202016Mondaypm31America/ChicagoMon, 17 Oct 2016 14:20:48 -05001 by Violater1 because: (no reason given)