The erectile dysfunction drug Viagra, may be of benefit to patients with enlarged hearts secondary to high blood pressure. Animal tests indicate some
benefit, and researchers are making plans to test the drug in humans. The drug was found to have reversed some of the enlargement in mice.
news.yahoo.com
WASHINGTON - Viagra may aid in the treatment of enlarged hearts that can result from high blood pressure, tests on animals indicate. Plans are under
way for a trial to determine if similar results occur in humans given the drug widely used to treat erectile dysfunction.
The drug, known generically as sildenafil citrate, blocked and even reversed some of the heart enlargement in mice with blood pressure stress, said
researchers led by Dr. David A. Kass of the Johns Hopkins University School of Medicine.
"A larger-than-normal heart is a serious medical condition, known as hypertrophy, and is a common feature of heart failure that can be fatal," Kass
said.
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Viagra was initially developed as a drug for pulmonary hypertension or high blood pressure in the lung vasculature. Early on its famous side effect
was noticed and now it is a billion dollar drug for erectile dysfunction. However, its uses are still being investigated. We are actually one of the
centers researching pediatric applications for the drug. Once the snickers and jokes fade away, the drug actually works well for those with pulmonary
hypertension.