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originally posted by: raymundoko
a reply to: soficrow
This post shows you have no idea what you are talking about. You are extremely confused on what exactly prions can effect epigenetically.
I suggest you start with the basics:
originally posted by: dr1234
And where does the information to code these prions come from?
...prions are infectious agents devoid of instructional nucleic acid . They propagate themselves without a genetic code, instead enciphering their infectious nature structurally, within the protein conformation itself.
…unlike other infective agents such as bacteria, protozoa, and viruses, they don't contain any genetic material. No DNA or RNA. Prions are just misfolded proteins but they are capable of spreading, causing disease, and evolving.
......If the prion uses information like a neuron would, there could be a lot more potential to the prion than my measly 10 bits.
That said, I really haven't a clue on how proteins in general and prions in specific "handle" their information
Conformational diversity and protein evolution – a 60-year-old hypothesis revisited
Complex organisms have evolved from a limited number of primordial genes and proteins. However, the mechanisms by which the earliest proteins evolved and then served as the origin for the present diversity of protein function are unknown. Here, we outline a hypothesis based on the ‘new view’ of proteins whereby one sequence can adopt multiple structures and functions. We suggest that such conformational diversity could increase the functional diversity of a limited repertoire of sequences and, thereby, facilitate the evolution of new proteins and functions from old ones.
……The ‘new view’ of proteins has prompted the revision of many facets of protein science. Here, we have outlined the intriguing implications that this ‘new view’ might have for protein evolution. The hypotheses described are supported by many properties of today’s proteins, including the recent demonstration of a linkage between conformational diversity and multi-specificity in antibodies  (Fig. 2). Moreover, although present-day enzymes do not necessarily retain the activities of their evolutionary precursors, it appears that enzymes that retain both the original and a newly evolved activity can be readily generated in the test tube [40,41].