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originally posted by: whereislogic
What you're perhaps thinking about is that somehow somewhere 1 organism gets a mutation that's beneficial but none of the detrimental ones, that is unrealistic if you observe how mutations work. If you're thinking (or acknowledging) that if 1 organism gets 1 beneficial mutation for every 10000 or more "detrimental" ones (I'm not exaggerating the actual statistics), that you can still think of that organism being fitter for its environment and going in the direction of for example prokaryotic unicellular bacteria to humans, then you're deceiving yourself with false reasoning.
originally posted by: SusanDonavon
I really have no idea what htis is aobut
Perhaps this video can be of help for those who don't get bogged down on the word "information" or the term "new information", regarding this subject of a slow but steady degradation of the information that is specifically required for the operations within living cells..."
...
Note once more (cause I have a feeling some people might not be able to resist starting that debate I'm thinking about now, in spite of my double 'note' now) that I'm not sharing the video above regarding the subject or terminology "increase of information" but regarding the subject of "a slow but steady degradation of the information that is specifically required for the operations within living cells" which is speaking of going from a state of functional order for this information that is specifically required for these specific operations, to a state of disfuntional disorder for this information that is specifically required for these specific operations (that's a lot more specific and has been observed statistically and experimentally in the way I described earlier in the comment).
[going back to that]
The effects of natural selection have already been accounted for in the video from the geneticist. It doesn't change what he's saying. I also tried to remind people of that when I was referring to the effect of "mutations acted upon by natural selection" over multiple generations (also because I was thinking of the thoughts you just expressed and attempting to address those right away, I'm often hoping to skip the figurative 'surface' of the line of argumentation). That longterm effect is genetic degradation according to all the statistics that have been observed in relation to what one could interpret as "beneficial", "detrimental" or "neutral" to the organisms (regarding their fitness for survival in a given environment and their overall health). As well as according to direct experiments of genetic lineages (organisms that are known to be genetically related through direct experimentation with those organisms, usually lineages of bacteria cause they reproduce nice and fast; but much experimentation has also been done with plants).
I explained how the ratio is irrelevant because detrimental genes are not passed down. You gave no response to this at all.
"You can select for a very bad gene, but you can't select for a typical deleterious gene; because a typical deleterious gene is too subtle, to tiny in its effect. it's like the rust atoms in your car, you don't see them so you can't select for them".
"Amazingly if you read carefully the literature, the technical literature of population genetics, over the last several decades; you will find many many of the world's best population geneticists who are saying "there's a fundamental problem with our theory, it doesn't really work!"
"1. if you have a very high mutation rate, with most of the mutations being bad, there's no selection scheme that could keep up with the mutations that could keep up with the population"
"that's not survival of the fittest, that's survival of the luckiest"
"so, selection can't sort out the good from the bad"
"we can summarize Sanford's argument as follows: 1) Newborns have 100+ de novo mutations 2) Most mutations have small negative effects 3) Natural selection can't remove all bad mutations 4) Therefore, human beings accumulate deleterious mutations with each generation"
2. Most people in the field think the human genome is clearly degenerating, but they dismiss this as merely arising due to relaxed selection. But those who have examined it most closely realize that even with intense selection there is still a profound problem (see many quotes within Appendix A of Genetic Entropy).
...
4. About 100 years ago, Fisher imagined that half of all mutations might be beneficial – because he knew almost nothing of modern biology. To him, genes were “beads on a string”. The essential elements of “Fisher’s Theorem” can now be rigorously falsified (paper in preparation). We now know that a gene essentially operates like executable computer code. In an executable computer program (or as in the text of an instruction manual), random changes of any of the zeros and ones (or text letters) will obviously be almost universally deleterious. By far, the most extensive analysis of mutation accumulation is the Long Term Evolution Experiment by Lenski et al., That work shows that the rate of beneficial mutations is less than 1 per million. Furthermore, that experiment shows that most of the documented beneficials were loss-of-function mutations, ...
...
6. The evidence for real world genetic entropy ... is seen in the past human genome (here), in the present human genome (Lynch, M. 2010. Rate, molecular spectrum, and consequences of human mutation. PNAS 107 (3): 961-968), in virus populations (H1N1, here), in the endangered cheetah population, and in bacteria (American Society for Microbiology, mbio.asm.org September/October 2014 Volume 5 Issue 5 e01377-14. and Koskiniemi et al., Selection-Driven Gene Loss in Bacteria, PLOS Genetics, 2012.).
originally posted by: whereislogic
I explained how the ratio is irrelevant because detrimental genes are not passed down. You gave no response to this at all.
I did respond to it multiple times, even before he started making those arguments, his suggestion is that it's natural selection that selects out (or weeds out) the detrimental genes so they are not passed down (see comments earlier to you). But natural selection has already been accounted for in the ratio or statistics and experimental observations of genetic lineages.