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I wasn't crazy about the idea, but it's hard for them not to work, unless a person is allergic to some of the compounds used. I'm 6'1" and weigh about 235 lbs. I saw when the midazolam was put into my I.V. and I remember saying, "ahhhh, the good stuff." That's all I recall until after I regained awareness.
I hate twilight anaesthetics. Don't work on me at all.