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Thousands of migraine patients could be cured by an operation - on their heart.
New research has shown that a hole-in-the-heart defect is twice as common in the million or so Britons who suffer from migraines.
The hole in the heart's wall allows blood that should be going to the lungs to leak into the supply feeding the brain, boosting levels of the brain chemical serotonin.
In the trial, which is backed by the Migraine Action Association, doctors will patch up up the hole with a surgical mesh in a one-hour keyhole operation.
This attempt to restore normal blood circulation follows reports that some patients who have had the defect repaired for other medical reasons no longer have migraines.