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The chromosomes were studied in a human intersex (“true hermaphrodite”) characterized by ambiguous external genitalia and abdominal gonads consisting of a left ovotestis and a right primitive testis. The tissues sampled for chromosome studies (two skin biopsies, right gonad and blood) contained cells having 46, 47 and 49 chromosomes and XX, XXY and XXYYY sex chromosomes respectively. This finding strongly supports the concept that testicular tissue develops only in the presence of the Y chromosome. It is considered plausible that all human íntersexes are chromosomal mosaics. The cytological investigations of the apparent exceptions so far reported in the literature (intersexes with XX sex chromosomes) have been confined to a single tissue specimen.
Meanwhile, it’s true that transgender young people experience higher rates of mental health challenges, like the patients in this study, but the mounting evidence indicates that it’s not because they are transgender, but because of how they are treated for being transgender.
In other words, if we treat transgender people better, they don't suffer as much depression. It's us that's the problem, not them.