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originally posted by: booyakasha
This is a book written in 1975 by a man named JW Armstrong. He claims that all cancers can be cured by a thing called urine therapy. If you look at the testimonies of people using this therapy it seems like mostly anything can be cured from this therapy.
aquariusthewaterbearer.com...
It's a very easy read. I haven't had cancer myself but after reading this book i joined a group of people on Facebook called "distilled waters". Some people in that group have had a lot of success using this therapy. If you read the testimonies of people you will see that, not only is this treatment free, but it works in 40 days tops supposedly.
Tumor cells have high-energetic and anabolic needs and are known to adapt their metabolism to be able to survive and keep proliferating under conditions of nutrient stress. We show that PKCζ deficiency promotes the plasticity necessary for cancer cells to reprogram their metabolism to utilize glutamine through the serine biosynthetic pathway in the absence of glucose. PKCζ represses the expression of two key enzymes of the pathway, PHGDH and PSAT1, and phosphorylates PHGDH at key residues to inhibit its enzymatic activity. Interestingly, the loss of PKCζ in mice results in enhanced intestinal tumorigenesis and increased levels of these two metabolic enzymes, whereas patients with low levels of PKCζ have a poor prognosis. Furthermore, PKCζ and caspase-3 activities are correlated with PHGDH levels in human intestinal tumors. Taken together, this demonstrates that PKCζ is a critical metabolic tumor suppressor in mouse and human cancer.
In addition to glucose, tumor cells can metabolize glutamine, whose transport into the cell is dramatically enhanced during transformation (DeBerardinis and Cheng, 2010; Fuchs and Bode, 2006). Glutamine is a very versatile metabolite because it can not only provide ATP by oxidation through the Krebs cycle but also generate nitrogen for nucleotide synthesis, and it is a precursor of glutathione, helping to control the side effects of oxidative stress
Here, we report that PKCζ-deficient cells reprogram their metabolism for the utilization of glutamine instead of glucose through the serine biosynthetic cascade controlled by 3-phosphoglycerate dehydrogenase (PHGDH). This is particularly relevant in light of recent findings suggesting a critical role for this newly identified metabolic cascade in oncogenesis (Locasale et al., 2011; Possemato et al., 2011).
...In this regard, our data demon strate that PKCζ is determinant of metabolic plasticity and suggest that attacking the Warburg effect would actually be effective in cancer therapy as long as PKCζ is activated.
Our findings demonstrate that PKCζ deficiency allows glucose-addicted human cancer cells to reprogram their metabolism in response to glucose deprivation by increasing the utilization of glutamine through a pathway that involves the generation of 3PG...
In summary, our data show that in addition to glucose utilization, the reprogramming of cellular metabolism to produce serine from glutamine underscores the importance of serine biosynthesis for tumor cell survival and establishes PKCζ as a critical player in this important metabolic pathway for cancer.
originally posted by: PeterMcFly
a reply to: Pardon?
Answer #2:
Have you at least taken the time to read the study you have thrown at my face?
"Control of Nutrient Stress-Induced Metabolic Reprogramming by PKCζ in Tumorigenesis" by Li Ma et al.
I have just finished reading it!
Summary:
Tumor cells have high-energetic and anabolic needs and are known to adapt their metabolism to be able to survive and keep proliferating under conditions of nutrient stress. We show that PKCζ deficiency promotes the plasticity necessary for cancer cells to reprogram their metabolism to utilize glutamine through the serine biosynthetic pathway in the absence of glucose. PKCζ represses the expression of two key enzymes of the pathway, PHGDH and PSAT1, and phosphorylates PHGDH at key residues to inhibit its enzymatic activity. Interestingly, the loss of PKCζ in mice results in enhanced intestinal tumorigenesis and increased levels of these two metabolic enzymes, whereas patients with low levels of PKCζ have a poor prognosis. Furthermore, PKCζ and caspase-3 activities are correlated with PHGDH levels in human intestinal tumors. Taken together, this demonstrates that PKCζ is a critical metabolic tumor suppressor in mouse and human cancer.
Basically it said that cancer cells are able to reprogram their metabilism to utilise glutamine when glucose is sparse...
You probably have no aptitude to read and comprehend scientific paper and thus rely on distorted and perverted interpretation of wannabe scientific journalist trying to interpret paper that they do not understand.
Further:
In addition to glucose, tumor cells can metabolize glutamine, whose transport into the cell is dramatically enhanced during transformation (DeBerardinis and Cheng, 2010; Fuchs and Bode, 2006). Glutamine is a very versatile metabolite because it can not only provide ATP by oxidation through the Krebs cycle but also generate nitrogen for nucleotide synthesis, and it is a precursor of glutathione, helping to control the side effects of oxidative stress
Here, we report that PKCζ-deficient cells reprogram their metabolism for the utilization of glutamine instead of glucose through the serine biosynthetic cascade controlled by 3-phosphoglycerate dehydrogenase (PHGDH). This is particularly relevant in light of recent findings suggesting a critical role for this newly identified metabolic cascade in oncogenesis (Locasale et al., 2011; Possemato et al., 2011).
Discussion:
...In this regard, our data demon strate that PKCζ is determinant of metabolic plasticity and suggest that attacking the Warburg effect would actually be effective in cancer therapy as long as PKCζ is activated.
Our findings demonstrate that PKCζ deficiency allows glucose-addicted human cancer cells to reprogram their metabolism in response to glucose deprivation by increasing the utilization of glutamine through a pathway that involves the generation of 3PG...
In summary, our data show that in addition to glucose utilization, the reprogramming of cellular metabolism to produce serine from glutamine underscores the importance of serine biosynthesis for tumor cell survival and establishes PKCζ as a critical player in this important metabolic pathway for cancer.
Are you trying to insult my intelligence?
Have you read the stuff you have thrown at me? I hope not... This is just a cretinic journalistic interpretation!
originally posted by: saadad
a reply to: Pardon?
So they make a study that 9/10 patients will survive on chemo or live longer, not sure now, but go back and reread what other guy said.
Also how do you comment that most oncologist won't take chemo?
I have a feeling that in this topic you don't read opposite side than yours.
originally posted by: saadad
So with chemo you can get few more years, but what if without it you can live like normal people do.
I have also read and know many people that went trough chemo and they are subscribed for meds for rest of their life's and some of them have really low quality of life
I m not expert in this field and did not read about this topic online. I only know that chemotherapy patients are subscribed for medication bfir rest of their lives.
This is true. You will not find any disagreement with that statement.
If they tell you that you need chemotherapy you should really make decision knowing all facts and not just because they tell you.
originally posted by: saadad
He was man above Hus time and if he refused chemotherapy it was the correct choice even if he didn't survive. People using it to promote chemotherapy are evil...
That depends upon the type of cancer:
Hows many chemotherapy patients survive? And how long do they live?
I know their lifespan us heavily shorted even if they survive.
Yes you are lucky one, but maybe someone who didn't do a chemo and is still alive will cone and post same thing.
According to the OP all the cancer was removed, plus some healthy tissue to boot.
I disagree, based on the level of the consequences of the gamble.
It's extremely taxing on the body (as you know yourself) and not something you just do 'just to be on the safe side'.