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Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer
The paper explained
A major goal in aging research is to increase the so-called ‘health span’ or the time of life free of disease. Telomeres have been linked with aging and disease and, in the case of mice, genetic manipulations that shorten or lengthen telomeres result, respectively, in decreased or increased longevity. Therapies that impact on telomere length are therefore expected to have an impact on health span.
Based on this notion, we tested the effects of a telomerase gene therapy in adult (1 year of age) and old (2 years of age) mice. Treatment of both groups of mice with an AAV of wide tropism expressing mouse telomerase (mTERT) demonstrated remarkable beneficial effects on health and fitness, improving several molecular biomarkers of aging. Moreover, telomerase-treated mice did not develop more neoplasias comparing to their control littermates, suggesting that the known tumorigenic activity of telomerase is severely decreased when expressed in adult or old organisms. Finally, re-introduction of mTERT in both 1- and 2-year old mice increased significantly its median lifespan (24 and 13%, respectively). These beneficial effects were not observed with a reporter virus (eGFP) or a catalytically inactive TERT (TERT-DN) demonstrating the strict dependency of an active telomerase complex.
Together, our results constitute a proof-of-principle of a role of mTERT in delaying physiological aging, improvement of health span, and extension of longevity in normal (wild type) mice. The gene therapy described here represents a novel type of therapeutic intervention against various age-related diseases.
originally posted by: Eilasvaleleyn
a reply to: Passerby1996
Hmm, not noble. My reasons are entirely selfish. Death is a lot more interesting than life, from my perspective. It's like the difference between a book you've read a hundred times and a book you've never even heard of.
It's also worth noting that my world-view is somewhat 'messed up.' I view life as an obligation I have to fulfill, rather than something I am lucky to be gifted with. While I do not hate it... As I said. Death is far more interesting and attractive, viewed through my eyes. I'd have no qualms with dropping dead, instantly, right now, if it weren't for the people whom would be saddened by my passing. It is for their sake that I cling to life, not my own.