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originally posted by: Anyafaj
But the teenager started to feel sick soon after and went to the school nurse with a racing heart rate and high blood pressure.
Reduced IQ? Are you serious? Some may suffer from SHORT TERM memory loss, but it has no effect on long term memory... Nor does it "induce" schizophrenia. There is ZERO actual evidence of this
The hippocampus is important to long-term memory (also known as episodic memory), which is the ability to remember autobiographical or life events.
The brain abnormalities and memory problems were observed during the individuals' early twenties, two years after they stopped smoking marijuana.
Young adults who abused cannabis as teens performed about 18 percent worse on long-term memory tests than young adults who never abused cannabis.
Teen cannabis users have poor long-term memory in adulthood
In the current study, Dr. Meier and colleagues used data from the Dunedin Longitudinal Study, which was conducted in Dunedin, New Zealand. This prospective study included a birth cohort of 1037 individuals born in 1972 and 1973, who were followed from birth and were seen every 2 years to age 38.
"This study has collected prospective life histories on its participants and had 95% retention," Dr. Meier said.
Participants' cannabis use was ascertained in interviews at ages 18, 21, 26, 32, and 38 years. IQ testing was done at age 8, 11, and 13 years, before the start of cannabis use, and again at age 38, after a pattern of persistent cannabis use had developed. One third of the cohort had never used cannabis.
After controlling for alcohol or drug dependence, socioeconomic status, and years of education, the researchers found that persistent cannabis use was associated with IQ decline when it was begun during the teenage years but not when begun in the adult years, after the age of 18.
Between the ages of 8 and 38 years, individuals who began using cannabis in adolescence and continued to use it for years thereafter lost an average of 8 IQ points. In contrast, IQ among individuals who never used cannabis actually rose slightly, Dr. Meier said. Cessation of cannabis did not restore IQ among teen-onset cannabis users, she added.
Cannabis Use in Teens Linked to Irreparable Drop in IQ
Epidemiological evidence suggests that cannabis use is a risk factor for schizophrenia, while cannabis use in individuals with a predisposition for schizophrenia results in an exacerbation of symptoms and worsening of the schizophrenic prognosis. The neurodevelopmental characteristic of adolescence probably creates a more vulnerable circumstance for cannabis to produce psychotic-like symptoms and possibly cause schizophrenia.
In the past few years there has been an increase in evidence of the important role of the endocannabinoid system in moderating adolescent neurodevelopmental processes such as synaptic pruning. We can speculate that adolescent exposure to cannabinoids might tamper with the normal developmental neuronal processes occurring in the still developing adolescent brain, thus leading to a predisposition to develop schizophrenia, possibly involving GABAergic and dopaminergic dysfunction. As with adults, there are definitely some adolescents that are more susceptible to the pro-psychotic effects of cannabis, possibly because of a genetic vulnerability such as a polymorphism in the COMT gene.
Longitudinal studies that evaluate adolescents prior to initiation of regular cannabis use and compare brain function indicators as well as the development of schizophrenia are required. Also, preclinical studies to further investigate the role of the endocannabinoid system in neurodevelopment, as well as molecular and neurochemical effects of adolescent cannabinoid exposure would greatly enhance the knowledge on the propensity for adolescent use of cannabis to induce schizophrenia.
Adolescent cannabis use and psychosis: epidemiology and neurodevelopmental models
The strongest evidence that cannabis use is a contributory cause of schizophrenia comes from longitudinal studies of large representative samples of the population who have been followed over time to see if cannabis users are at higher risk of developing schizophrenia. The earliest such study was a 15-year prospective investigation of cannabis use and schizophrenia in 50,465 Swedish conscripts. The study found that those who had tried cannabis by age 18 were 2.4 times more likely to be diagnosed with schizophrenia than those who had not 16 and the risk of this diagnosis increased with the frequency of cannabis use. The risks were substantially reduced but still significant after statistical adjustment for variables that were related to the risk of developing schizophrenia.
Cannabis use and the risk of developing a psychotic disorder
Røgeberg is careful to note that his reinterpretation of the data doesn’t entirely discredit the original study, but he does write that its “methodology is flawed and the causal inference drawn from the results premature.”
Long-Term Marijuana Use Could Have Zero Effect on IQ Read more: www.smithsonianmag.com...
originally posted by: Xtrozero
originally posted by: CharlieSpeirs
Marijuana has never paralysed anyone... Ever!
Marijuana never will paralyse anyone... Ever!
Here in Washington where pot is now legal there is an issue with the amount of THC that a brownie can hold that is basically at a untested level when people use oils as the THC base. There is cases of what is being determine as over dose with some serious side effects that I do not think a person smoking can achieve.
originally posted by: OccamsRazor04
Actually quite a few drugs are able to have the opposite effect in some people.