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Anticoagulant rodenticides were first discovered in the 1940 s and have since become the most widely used toxicants for commensal rodent control. Rodents poisoned with anticoagulants die from internal bleeding, the result of loss of the blood s clotting ability and damage to the capillaries. Prior to death, the animal exhibits increasing weakness due to blood loss, though appetite and body weight are not specifically affected. Because anticoagulant baits are slow in action (several days following the ingestion of a lethal dose), the target animal is unable to associate its illness with the bait eaten. Therefore, bait shyness does not occur. This delayed action also has a safety advantage because it provides time to administer the antidote (vitamin K1) to save pets, livestock, and people who may have accidentally ingested the bait.