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A group of researchers led by Prof Kim Lewis of Northeastern University in Boston, Massachusetts, has discovered a new antibiotic that eliminates Methicillin-resistant Staphylococcus aureus (MRSA), Mycobacterium tuberculosis, Streptococcus pneumoniae, Bacillus anthracis and other dangerous pathogens without encountering any detectable resistance.
“NovoBiotic has since assembled about 50,000 strains of uncultured bacteria and discovered 25 new antibiotics, of which teixobactin is the latest and most interesting,” said Prof Lewis, who is the senior author of the paper published in the journal Nature.
Uncultured bacteria make up approximately 99% of all species in external environments, and are an untapped source of new antibiotics. We developed several methods to grow uncultured organisms by cultivation in situ or by using specific growth factors. Here we report a new antibiotic that we term teixobactin, discovered in a screen of uncultured bacteria. Teixobactin inhibits cell wall synthesis by binding to a highly conserved motif of lipid II (precursor of peptidoglycan) and lipid III (precursor of cell wall teichoic acid). We did not obtain any mutants of Staphylococcus aureus or Mycobacterium tuberculosis resistant to teixobactin. The properties of this compound suggest a path towards developing antibiotics that are likely to avoid development of resistance.
originally posted by: Yeahkeepwatchingme
Until they develop a resistance to this it's a victory I guess..